Multiple Desmoplastic Cellular Neurothekeomas in Child: Report of the First Oral Case and Review of the Literature

Cellular neurothekeomas (CNs) are distinctive benign tumors of uncertain histogenesis, with predilection for the skin of the head and neck region. We describe the first case of multiple desmoplastic CNs (DCNs) affecting the oral cavity in a 9-year-old girl. Histopathologic evaluation showed a prolif...

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Bibliographic Details
Published in:Head & neck pathology (Totowa, N.J.) N.J.), 2018-03, Vol.12 (1), p.75-81
Main Authors: Almeida, Tatiana Fernandes Araújo, Verli, Flaviana Dornela, dos Santos, Cássio Roberto Rocha, Falci, Saulo Gabriel Moreira, Almeida, Luciana Yamamoto, Almeida, Lana Kei Yamamoto, Mesquita, Ana Terezinha Marques, León, Jorge Esquiche
Format: Article
Language:English
Subjects:
Dentistry
Medicine
Medicine & Public Health
Oral and Maxillofacial Surgery
Original Paper
Otorhinolaryngology
Pathology
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Summary:Cellular neurothekeomas (CNs) are distinctive benign tumors of uncertain histogenesis, with predilection for the skin of the head and neck region. We describe the first case of multiple desmoplastic CNs (DCNs) affecting the oral cavity in a 9-year-old girl. Histopathologic evaluation showed a proliferation of spindle and epithelioid cells, forming nests and bundles, supported by exuberant fibrous stroma, as well as scattered multinucleated floret-like giant cells. The tumor cells were immunopositive for vimentin, CD63, CD56, whereas AE1/AE3, S100, CD34, α-SMA, GFAP, EMA, CD57 and NSE were negative. Ki-67 was
ISSN:1936-055X
1936-0568
DOI:10.1007/s12105-017-0828-8