Characteristics of quantitative perfusion parameters on dynamic contrast‐enhanced MRI in mammographically occult breast cancer

• Published in: Journal of applied clinical medical physics 2016-09, Vol.17 (5), p.377-390
• Main Authors: Ryu, Jung Kyu, Rhee, Sun Jung, Song, Jeong Yoon, Cho, Soo Hyun, Jahng, Geon‐Ho
• Format: Article
• Language: English
• Subjects: Adult; breast cancer; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - pathology; Carcinoma, Ductal, Breast - diagnostic imaging; Carcinoma, Ductal, Breast - pathology; Carcinoma, Lobular - diagnostic imaging; Carcinoma, Lobular - pathology; Contrast Media; dynamic contrast‐enhanced perfusion; Female; Humans; Image Enhancement - methods; Image Processing, Computer-Assisted - methods; magnetic resonance imaging; Magnetic Resonance Imaging - methods; Mammography - methods; Medical Imaging; Middle Aged; occult breast cancer; Perfusion; quantitative analysis; Retrospective Studies
• ISSN: 1526-9914; 1526-9914
• DOI: 10.1120/jacmp.v17i5.6091

The purpose of this study was to compare the characteristics of quantitative perfusion parameters obtained from dynamic contrast‐enhanced (DCE) magnetic resonance imaging (MRI) in patients with mammographically occult (MO) breast cancers and those with mammographically visible (MV) breast cancers. Quantitative parameters (AUC, Ktrans,kep,ve,vp, and wi) from 13 MO breast cancers and 16 MV breast cancers were mapped after the DCE‐MRI data were acquired. Various prognostic factors, including axillary nodal status, estrogen receptor (ER), progesterone receptor (PR), Ki‐67, p53, E‐cadherin, and human epidermal growth factor receptor 2 (HER2) were obtained in each group. Fisher's exact test was used to compare any differences of the various prognostic factors between the two groups. The Mann‐Whitney U test was applied to compare the quantitative parameters between these two groups. Finally, Spearman's correlation was used to investigate the relationships between perfusion indices and four factors — age, tumor size, Ki‐67, and p53 — for each group. Although age, tumor size, and the prognostic factors were not statistically different between the two groups, the mean values of the quantitative parameters, except wi in the MV group, were higher than those in the MO group without statistical significance (p=0.219). The kep value was significantly different between the two groups (p=0.048), but the other parameters were not. In the MO group, vp with size, ve with p53, and Ktrans and vp with Ki‐67 had significant correlations (p