FOXO1: Another avenue for treating digestive malignancy?

Digestive malignancies are the leading cause of mortality among all neoplasms, contributing to estimated 3 million deaths in 2012 worldwide. The mortality rate hassurpassed lung cancer and prostate cancer in recent years. The transcription factor Forkhead Box O1 (FOXO1) is a key member of Forkhead B...

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Published in:Seminars in cancer biology 2018-06, Vol.50, p.124-131
Main Authors: Shi, Feiyu, Li, Tian, Liu, Zhi, Qu, Kai, Shi, Chengxin, Li, Yaguang, Qin, Qian, Cheng, Liang, Jin, Xin, Yu, Tianyu, Di, Wencheng, Que, Jianwen, Xia, Hongping, She, Junjun
Format: Article
Language:English
Subjects:
Akt
Carcinogenesis - genetics
Digestive malignancy
Disease Progression
Forkhead box O1
Forkhead Box Protein O1 - genetics
Gastrointestinal Neoplasms - genetics
Gastrointestinal Neoplasms - pathology
Hepatocellular carcinoma
Humans
Liver Neoplasms - genetics
Liver Neoplasms - pathology
microRNA
Neoplasm Metastasis
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Summary:Digestive malignancies are the leading cause of mortality among all neoplasms, contributing to estimated 3 million deaths in 2012 worldwide. The mortality rate hassurpassed lung cancer and prostate cancer in recent years. The transcription factor Forkhead Box O1 (FOXO1) is a key member of Forkhead Box family, regulating diverse cellular functions during tumor initiation, progression and metastasis. In this review, we focus on recent studies investigating the antineoplastic role of FOXO1 in digestive malignancy. This review aims to serve as a guide for further research and implicate FOXO1 as a potent therapeutic target in digestive malignancy.
ISSN:1044-579X
1096-3650
1096-3650
DOI:10.1016/j.semcancer.2017.09.009