Skin Necrosis Due to the Extravasation of Irritant Anticancer Agents

A 70-year-old man with malignant lymphoma was subjected to a fourth course of chemotherapy using gemcitabine and cisplatin. During the intravenous infusion of anticancer agents, pain and redness was observed at the site of insertion. The patient was subsequently treated with the strongest topical st...

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Bibliographic Details
Published in:Internal Medicine 2018/03/01, Vol.57(5), pp.757-760
Main Authors: Okuda, Hiroto, Masatsugu, Asako, Sijimaya, Takako, Arai, Rie
Format: Article
Language:English
Subjects:
Aged
anticancer agent
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antitumor agents
Cancer
Case Report
Chemotherapy
Cisplatin
Cisplatin - administration & dosage
Cisplatin - adverse effects
Deoxycytidine - administration & dosage
Deoxycytidine - adverse effects
Deoxycytidine - analogs & derivatives
Dermis
Extravasation
Gangrene
Gemcitabine
Humans
Infusions, Intravenous
Injection Site Reaction - etiology
Internal medicine
Intravenous administration
Intravenous infusion
Irritants - administration & dosage
Irritants - adverse effects
Lymphoma
Lymphoma - drug therapy
Male
Necrosis
Necrosis - chemically induced
Pain
Skin
Skin - pathology
skin necrosis
Steroid hormones
Steroids
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Description
Summary:A 70-year-old man with malignant lymphoma was subjected to a fourth course of chemotherapy using gemcitabine and cisplatin. During the intravenous infusion of anticancer agents, pain and redness was observed at the site of insertion. The patient was subsequently treated with the strongest topical steroids and topical cooling agents. However, 2 weeks later, the affected area turned yellow, and the histopathological findings revealed skin necrosis of the entire dermis layer. It took two and a half months to cure the lesion. Close attention should be paid to the development of skin necrosis even when irritant anticancer agents such as gemcitabine and cisplatin are administered.
ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.9329-17