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Skin Necrosis Due to the Extravasation of Irritant Anticancer Agents
A 70-year-old man with malignant lymphoma was subjected to a fourth course of chemotherapy using gemcitabine and cisplatin. During the intravenous infusion of anticancer agents, pain and redness was observed at the site of insertion. The patient was subsequently treated with the strongest topical st...
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| Published in: | Internal Medicine 2018/03/01, Vol.57(5), pp.757-760 |
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| Main Authors: | , , , |
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| Language: | English |
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| container_end_page | 760 |
| container_issue | 5 |
| container_start_page | 757 |
| container_title | Internal Medicine |
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| creator | Okuda, Hiroto Masatsugu, Asako Sijimaya, Takako Arai, Rie |
| description | A 70-year-old man with malignant lymphoma was subjected to a fourth course of chemotherapy using gemcitabine and cisplatin. During the intravenous infusion of anticancer agents, pain and redness was observed at the site of insertion. The patient was subsequently treated with the strongest topical steroids and topical cooling agents. However, 2 weeks later, the affected area turned yellow, and the histopathological findings revealed skin necrosis of the entire dermis layer. It took two and a half months to cure the lesion. Close attention should be paid to the development of skin necrosis even when irritant anticancer agents such as gemcitabine and cisplatin are administered. |
| doi_str_mv | 10.2169/internalmedicine.9329-17 |
| format | article |
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Close attention should be paid to the development of skin necrosis even when irritant anticancer agents such as gemcitabine and cisplatin are administered.</description><identifier>ISSN: 0918-2918</identifier><identifier>ISSN: 1349-7235</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.9329-17</identifier><identifier>PMID: 29093414</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Aged ; anticancer agent ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Antitumor agents ; Cancer ; Case Report ; Chemotherapy ; Cisplatin ; Cisplatin - administration & dosage ; Cisplatin - adverse effects ; Deoxycytidine - administration & dosage ; Deoxycytidine - adverse effects ; Deoxycytidine - analogs & derivatives ; Dermis ; Extravasation ; Gangrene ; Gemcitabine ; Humans ; Infusions, Intravenous ; Injection Site Reaction - etiology ; Internal medicine ; Intravenous administration ; Intravenous infusion ; Irritants - administration & dosage ; Irritants - adverse effects ; Lymphoma ; Lymphoma - drug therapy ; Male ; Necrosis ; Necrosis - chemically induced ; Pain ; Skin ; Skin - pathology ; skin necrosis ; Steroid hormones ; Steroids</subject><ispartof>Internal Medicine, 2018/03/01, Vol.57(5), pp.757-760</ispartof><rights>2018 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2018</rights><rights>Copyright © 2018 by The Japanese Society of Internal Medicine 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c666t-38ba4401ccd25fcf3e477dcd4706c45def2ac2d1e96b4642db9480e1f67132a23</citedby><cites>FETCH-LOGICAL-c666t-38ba4401ccd25fcf3e477dcd4706c45def2ac2d1e96b4642db9480e1f67132a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874355/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874355/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29093414$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okuda, Hiroto</creatorcontrib><creatorcontrib>Masatsugu, Asako</creatorcontrib><creatorcontrib>Sijimaya, Takako</creatorcontrib><creatorcontrib>Arai, Rie</creatorcontrib><title>Skin Necrosis Due to the Extravasation of Irritant Anticancer Agents</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 70-year-old man with malignant lymphoma was subjected to a fourth course of chemotherapy using gemcitabine and cisplatin. During the intravenous infusion of anticancer agents, pain and redness was observed at the site of insertion. The patient was subsequently treated with the strongest topical steroids and topical cooling agents. However, 2 weeks later, the affected area turned yellow, and the histopathological findings revealed skin necrosis of the entire dermis layer. It took two and a half months to cure the lesion. Close attention should be paid to the development of skin necrosis even when irritant anticancer agents such as gemcitabine and cisplatin are administered.</description><subject>Aged</subject><subject>anticancer agent</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Antitumor agents</subject><subject>Cancer</subject><subject>Case Report</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>Cisplatin - administration & dosage</subject><subject>Cisplatin - adverse effects</subject><subject>Deoxycytidine - administration & dosage</subject><subject>Deoxycytidine - adverse effects</subject><subject>Deoxycytidine - analogs & derivatives</subject><subject>Dermis</subject><subject>Extravasation</subject><subject>Gangrene</subject><subject>Gemcitabine</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Injection Site Reaction - etiology</subject><subject>Internal medicine</subject><subject>Intravenous administration</subject><subject>Intravenous infusion</subject><subject>Irritants - administration & dosage</subject><subject>Irritants - adverse effects</subject><subject>Lymphoma</subject><subject>Lymphoma - drug therapy</subject><subject>Male</subject><subject>Necrosis</subject><subject>Necrosis - chemically induced</subject><subject>Pain</subject><subject>Skin</subject><subject>Skin - pathology</subject><subject>skin necrosis</subject><subject>Steroid hormones</subject><subject>Steroids</subject><issn>0918-2918</issn><issn>1349-7235</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNplkU1vEzEQhi0EoqHwF5AlLly2-NvrC1LUD6hUlUPL2XK8s4nDxltsbwX_vl4lRFAu44OfeWfmfRHClJwxqsynEAuk6IYddMGHCGeGM9NQ_QItKBem0YzLl2hBDG0bVssJepPzlhDeasNeoxNmiOGCigW6uPsRIr4Fn8YcMr6YAJcRlw3gy18luUeXXQljxGOPr1MKxcWCl7EE76KHhJdriCW_Ra96N2R4d3hP0fery_vzr83Nty_X58ubxiulSsPblROCUO87JnvfcxBad74TmigvZAc9c551FIxaCSVYtzKiJUB7pSlnjvFT9Hmv-zCt6um-zk5usA8p7Fz6bUcX7L8_MWzseny0stWCS1kFPh4E0vhzglzsLmQPw-AijFO21MjqJONkRj88Q7fjNHueLSNUSGKMVJVq99TsX07QH5ehxM5R2edR2TkqS3Vtff_3McfGP9lU4HYPbHNxazgCLlX7B_hfWWor53KYcAT9xiULkT8BKm2ywA</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Okuda, Hiroto</creator><creator>Masatsugu, Asako</creator><creator>Sijimaya, Takako</creator><creator>Arai, Rie</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180101</creationdate><title>Skin Necrosis Due to the Extravasation of Irritant Anticancer Agents</title><author>Okuda, Hiroto ; Masatsugu, Asako ; Sijimaya, Takako ; Arai, Rie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c666t-38ba4401ccd25fcf3e477dcd4706c45def2ac2d1e96b4642db9480e1f67132a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>anticancer agent</topic><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Antitumor agents</topic><topic>Cancer</topic><topic>Case Report</topic><topic>Chemotherapy</topic><topic>Cisplatin</topic><topic>Cisplatin - administration & dosage</topic><topic>Cisplatin - adverse effects</topic><topic>Deoxycytidine - administration & dosage</topic><topic>Deoxycytidine - adverse effects</topic><topic>Deoxycytidine - analogs & derivatives</topic><topic>Dermis</topic><topic>Extravasation</topic><topic>Gangrene</topic><topic>Gemcitabine</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Injection Site Reaction - etiology</topic><topic>Internal medicine</topic><topic>Intravenous administration</topic><topic>Intravenous infusion</topic><topic>Irritants - administration & dosage</topic><topic>Irritants - adverse effects</topic><topic>Lymphoma</topic><topic>Lymphoma - drug therapy</topic><topic>Male</topic><topic>Necrosis</topic><topic>Necrosis - chemically induced</topic><topic>Pain</topic><topic>Skin</topic><topic>Skin - pathology</topic><topic>skin necrosis</topic><topic>Steroid hormones</topic><topic>Steroids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okuda, Hiroto</creatorcontrib><creatorcontrib>Masatsugu, Asako</creatorcontrib><creatorcontrib>Sijimaya, Takako</creatorcontrib><creatorcontrib>Arai, Rie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okuda, Hiroto</au><au>Masatsugu, Asako</au><au>Sijimaya, Takako</au><au>Arai, Rie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skin Necrosis Due to the Extravasation of Irritant Anticancer Agents</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>57</volume><issue>5</issue><spage>757</spage><epage>760</epage><pages>757-760</pages><issn>0918-2918</issn><issn>1349-7235</issn><eissn>1349-7235</eissn><abstract>A 70-year-old man with malignant lymphoma was subjected to a fourth course of chemotherapy using gemcitabine and cisplatin. During the intravenous infusion of anticancer agents, pain and redness was observed at the site of insertion. The patient was subsequently treated with the strongest topical steroids and topical cooling agents. However, 2 weeks later, the affected area turned yellow, and the histopathological findings revealed skin necrosis of the entire dermis layer. It took two and a half months to cure the lesion. Close attention should be paid to the development of skin necrosis even when irritant anticancer agents such as gemcitabine and cisplatin are administered.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>29093414</pmid><doi>10.2169/internalmedicine.9329-17</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Internal Medicine, 2018/03/01, Vol.57(5), pp.757-760 |
| issn | 0918-2918 1349-7235 1349-7235 |
| language | eng |
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| source | PubMed (Medline) |
| subjects | Aged anticancer agent Antineoplastic Combined Chemotherapy Protocols - adverse effects Antitumor agents Cancer Case Report Chemotherapy Cisplatin Cisplatin - administration & dosage Cisplatin - adverse effects Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Dermis Extravasation Gangrene Gemcitabine Humans Infusions, Intravenous Injection Site Reaction - etiology Internal medicine Intravenous administration Intravenous infusion Irritants - administration & dosage Irritants - adverse effects Lymphoma Lymphoma - drug therapy Male Necrosis Necrosis - chemically induced Pain Skin Skin - pathology skin necrosis Steroid hormones Steroids |
| title | Skin Necrosis Due to the Extravasation of Irritant Anticancer Agents |
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