LINE-1 hypomethylation is inversely correlated with UHRF1 overexpression in gastric cancer

DNA methylation is an important epigenetic modification that alters gene expression; DNA hypomethylation contributes to tumorigenesis through multiple processes. In the present study, the methylation of long interspersed element-1 (LINE-1) in 95 gastric cancer (GC) tissues and matched adjacent norma...

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Bibliographic Details
Published in:Oncology letters 2018-05, Vol.15 (5), p.6666-6670
Main Authors: Hong, Jang Hee, Jin, Eun-Heui, Kim, Soyeon, Song, Kyu-Sang, Sung, Jae Kyu
Format: Article
Language:English
Subjects:
Care and treatment
Classification
Deoxyribonucleic acid
Development and progression
DNA
DNA methylation
Epigenetics
Gastric cancer
Gene expression
Genetic aspects
Health aspects
Infections
Oncogenes
Oncology
Stomach cancer
Studies
Tumorigenesis
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Description
Summary:DNA methylation is an important epigenetic modification that alters gene expression; DNA hypomethylation contributes to tumorigenesis through multiple processes. In the present study, the methylation of long interspersed element-1 (LINE-1) in 95 gastric cancer (GC) tissues and matched adjacent normal tissues was investigated by pyrosequencing. LINE-1 methylation was compared with the expression of ubiquitin-like with PHD and ring-finger protein 1 (UHRF1), an essential regulator of DNA methylation, using reverse transcription-quantitative polymerase chain reaction. Significant hypomethylation of LINE-1 and overexpression of UHRF1 were observed in GC tissues compared with the matched controls (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2018.8121