Experimental and Numerical Modeling of Aerosol Delivery for Preterm Infants

• Published in: International journal of environmental research and public health 2018-02, Vol.15 (3), p.423
• Main Authors: Aramendia, Iñigo, Fernandez-Gamiz, Unai, Lopez-Arraiza, Alberto, Rey-Santano, Carmen, Mielgo, Victoria, Basterretxea, Francisco Jose, Sancho, Javier, Gomez-Solaetxe, Miguel Angel
• Format: Article
• Language: English
• Subjects: Administration, Inhalation; Aerodynamics; Aerosols; Air flow; Babies; Clinical trials; Computational fluid dynamics; Computer applications; Flow velocity; Fluid dynamics; Fluorocarbons - therapeutic use; Humans; Hydrodynamics; Infant, Newborn; Infant, Premature; Infants; Inhalation; Intubation; Liquid Ventilation - methods; Lungs; Mass distribution; Mathematical models; Medical instruments; Models, Theoretical; Newborn babies; Particle Size; Pediatrics; Perfluorocarbons; Perfluorodecalin; Premature babies; Pressure; Respiration; Respiratory distress syndrome; Respiratory Distress Syndrome, Newborn - therapy; Surfactants; Ventilators
• ISSN: 1660-4601; 1661-7827; 1660-4601
• DOI: 10.3390/ijerph15030423

Respiratory distress syndrome (RDS) represents one of the major causes of mortality among preterm infants, and the best approach to treat it is an open research issue. The use of perfluorocarbons (PFC) along with non-invasive respiratory support techniques has proven the usefulness of PFC as a complementary substance to achieve a more homogeneous surfactant distribution. The aim of this work was to study the inhaled particles generated by means of an intracorporeal inhalation catheter, evaluating the size and mass distribution of different PFC aerosols. In this article, we discuss different experiments with the PFC perfluorodecalin (PFD) and FC75 with a driving pressure of 4-5 bar, evaluating properties such as the aerodynamic diameter (D ), since its value is directly linked to particle deposition in the lung. Furthermore, we develop a numerical model with computational fluid dynamics (CFD) techniques. The computational results showed an accurate prediction of the airflow axial velocity at different downstream positions when compared with the data gathered from the real experiments. The numerical validation of the cumulative mass distribution for PFD particles also confirmed a closer match with the experimental data measured at the optimal distance of 60 mm from the catheter tip. In the case of FC75, the cumulative mass fraction for particles above 10 µm was considerable higher with a driving pressure of 5 bar. These numerical models could be a helpful tool to assist parametric studies of new non-invasive devices for the treatment of RDS in preterm infants.