PEO-PPO-PEO Tri-Block Copolymers for Gene Delivery Applications in Human Regenerative Medicine-An Overview

Lineal (poloxamers or Pluronic ) or X-shaped (poloxamines or Tetronic ) amphiphilic tri-block copolymers of poly(ethylene oxide) and poly(propylene oxide) (PEO-PPO-PEO) have been broadly explored for controlled drug delivery in different regenerative medicine approaches. The ability of these copolym...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-03, Vol.19 (3), p.775
Main Authors: Rey-Rico, Ana, Cucchiarini, Magali
Format: Article
Language:English
Subjects:
Block copolymers
Copolymers
Drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Drugs
Ethylene oxide
Expression vectors
Gene transfer
Gene Transfer Techniques
Humans
Informatics
Medicine
Micelles
Molecular weight
Pharmaceuticals
Physiology
Poloxamers
Polyethylene Glycols - adverse effects
Polyethylene Glycols - chemistry
Polyethylene oxide
Propylene
Propylene Glycols - adverse effects
Propylene Glycols - chemistry
Regenerative medicine
Regenerative Medicine - methods
Review
Sol-gel processes
Tissue engineering
Viscosity
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Summary:Lineal (poloxamers or Pluronic ) or X-shaped (poloxamines or Tetronic ) amphiphilic tri-block copolymers of poly(ethylene oxide) and poly(propylene oxide) (PEO-PPO-PEO) have been broadly explored for controlled drug delivery in different regenerative medicine approaches. The ability of these copolymers to self-assemble as micelles and to undergo sol-to-gel transitions upon heating has endowed the denomination of "smart" or "intelligent" systems. The use of PEO-PPO-PEO copolymers as gene delivery systems is a powerful emerging strategy to improve the performance of classical gene transfer vectors. This review summarizes the state of art of the application of PEO-PPO-PEO copolymers in both nonviral and viral gene transfer approaches and their potential as gene delivery systems in different regenerative medicine approaches.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19030775