Comparison of the effect of daily versus bolus dose maternal vitamin D3 supplementation on the 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 ratio

Supplementing lactating mothers with high doses of vitamin D3 can adequately meet vitamin D requirements of the breastfed infant. We compared the effect of bolus versus daily vitamin D3 dosing in lactating mothers on vitamin D3 catabolism. We hypothesized that catabolism of 25(OH)D3 to 24,25(OH)2D3...

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Bibliographic Details
Published in:Bone (New York, N.Y.) N.Y.), 2018-05, Vol.110, p.321-325
Main Authors: Ketha, Hemamalini, Thacher, Tom D., Oberhelman, Sara S., Fischer, Philip R., Singh, Ravinder J., Kumar, Rajiv
Format: Article
Language:English
Subjects:
Catabolism
Lactation
LC-MS/MS
Nutrition
Safety
Vitamin D metabolism
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Summary:Supplementing lactating mothers with high doses of vitamin D3 can adequately meet vitamin D requirements of the breastfed infant. We compared the effect of bolus versus daily vitamin D3 dosing in lactating mothers on vitamin D3 catabolism. We hypothesized that catabolism of 25(OH)D3 to 24,25(OH)2D3 would be greater in the bolus than in the daily dose group. Randomized controlled trial (clinicaltrials.govNCT01240265) in 40 lactating women. Subjects were randomized to receive vitamin D3 orally, either a single dose of 150,000IU or 5000IU daily for 28days. Vitamin D metabolites were measured in serum and breast milk at baseline, 1, 3, 7, 14 and 28days. Temporal changes in the serum 24,25(OH)2D3/25(OH)D3 ratio. The concentration of serum 24,25(OH)2D3 was directly related to that of 25(OH)D in both groups (r2=0.63; p
ISSN:8756-3282
1873-2763
DOI:10.1016/j.bone.2018.02.024