Progesterone activation of zebrafish mineralocorticoid receptor may influence growth of some transplanted tumors

Katsu and Baker examine the progesterone activation of zebrafish mineralocorticoid receptor that may influence growth of some transplanted tumors. They comment on a study which provides strong evidence for the benefits of studying the effects of drugs on the growth of human colon cancer explants in...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2018-03, Vol.115 (13), p.E2908-E2909
Main Authors: Katsu, Yoshinao, Baker, Michael E
Format: Article
Language:English
Subjects:
Activation
Biological Sciences
Colon
Colon cancer
Colorectal cancer
Danio rerio
Drugs
Explants
Human body
Letters
Progesterone
Transplants
Transplants & implants
Tumors
Zebrafish
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Summary:Katsu and Baker examine the progesterone activation of zebrafish mineralocorticoid receptor that may influence growth of some transplanted tumors. They comment on a study which provides strong evidence for the benefits of studying the effects of drugs on the growth of human colon cancer explants in zebrafish to identify those drugs that will be effective in treating a specific patient’s tumor. The work suggests that a similar approach using xeno-transplants of other diseased tissues in zebrafish may be used profitably to find personalized drugs to treat these diseases.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1802441115