Methanobactins: Maintaining copper homeostasis in methanotrophs and beyond

Methanobactins (Mbns) are ribosomally produced, post-translationally modified natural products that bind copper with high affinity and specificity. Originally identified in methanotrophic bacteria, which have a high need for copper, operons encoding these compounds have also been found in many non-m...

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Bibliographic Details
Published in:The Journal of biological chemistry 2018-03, Vol.293 (13), p.4606-4615
Main Authors: Kenney, Grace E., Rosenzweig, Amy C.
Format: Article
Language:English
Subjects:
Bacteria - metabolism
bacterial genetics
Bacterial Proteins - metabolism
BASIC BIOLOGICAL SCIENCES
biochemistry & molecular biology
Biological Transport, Active - physiology
chalkophore
Copper - metabolism
copper transport
Homeostasis - physiology
Imidazoles
INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Membrane Proteins - metabolism
metal homeostasis
metallophore
metalloprotein
methanobactin
methanotrophy
Minireviews
Oligopeptides - biosynthesis
RiPPs
siderophore
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Summary:Methanobactins (Mbns) are ribosomally produced, post-translationally modified natural products that bind copper with high affinity and specificity. Originally identified in methanotrophic bacteria, which have a high need for copper, operons encoding these compounds have also been found in many non-methanotrophic bacteria. The proteins responsible for Mbn biosynthesis include several novel enzymes. Mbn transport involves export through a multidrug efflux pump and re-internalization via a TonB-dependent transporter. Release of copper from Mbn and the molecular basis for copper regulation of Mbn production remain to be elucidated. Future work is likely to result in the identification of new enzymatic chemistry, opportunities for bioengineering and drug targeting of copper metabolism, and an expanded understanding of microbial metal homeostasis.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.TM117.000185