TGF-β1 Signaling and Tissue Fibrosis

Activation of TGF-β1 initiates a program of temporary collagen accumulation important to wound repair in many organs. However, the outcome of temporary extracellular matrix strengthening all too frequently morphs into progressive fibrosis, contributing to morbidity and mortality worldwide. To avoid...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in biology 2018-04, Vol.10 (4), p.a022293
Main Authors: Kim, Kevin K, Sheppard, Dean, Chapman, Harold A
Format: Article
Language:English
Subjects:
Accumulation
Animals
Apoptosis
Cell Proliferation
Collagen
Collagen - metabolism
Epithelial-Mesenchymal Transition
Extracellular matrix
Feedback, Physiological
Fibrosis
Humans
Integrins - metabolism
Integrins - physiology
Mice
Models, Biological
Morbidity
Organs
PERSPECTIVES
Repair
Signal Transduction
Signaling
Transforming Growth Factor beta1 - genetics
Transforming Growth Factor beta1 - metabolism
Transforming Growth Factor beta1 - physiology
Transforming growth factor-b1
Wound Healing
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Summary:Activation of TGF-β1 initiates a program of temporary collagen accumulation important to wound repair in many organs. However, the outcome of temporary extracellular matrix strengthening all too frequently morphs into progressive fibrosis, contributing to morbidity and mortality worldwide. To avoid this maladaptive outcome, TGF-β1 signaling is regulated at numerous levels and intimately connected to feedback signals that limit accumulation. Here, we examine the current understanding of the core functions of TGF-β1 in promoting collagen accumulation, parallel pathways that promote physiological repair, and pathological triggers that tip the balance toward progressive fibrosis. Implicit in better understanding of these processes is the identification of therapeutic opportunities that will need to be further advanced to limit or reverse organ fibrosis.
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a022293