Prognostic performance of serial in‐hospital measurements of copeptin and multiple novel biomarkers among patients with worsening heart failure: results from the MOLITOR study

Aims In heart failure, various biomarkers are established for diagnosis and risk stratification; however, little is known about the relevance of serial measurements during an episode worsening heart failure (WHF). This study sought to investigate the trajectory of natriuretic peptides and multiple n...

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Bibliographic Details
Published in:ESC Heart Failure 2018-04, Vol.5 (2), p.288-296
Main Authors: Düngen, Hans‐Dirk, Tscholl, Verena, Obradovic, Danilo, Radenovic, Sara, Matic, Dragan, Musial Bright, Lindy, Tahirovic, Elvis, Marx, Almuth, Inkrot, Simone, Hashemi, Djawid, Veskovic, Jovan, Apostolovic, Svetlana, Haehling, Stephan, Doehner, Wolfram, Cvetinovic, Natasa, Lainscak, Mitja, Pieske, Burkert, Edelmann, Frank, Trippel, Tobias, Loncar, Goran
Format: Article
Language:English
Subjects:
Aged
Atrial Natriuretic Factor - blood
Biomarker trajectory
Biomarkers
Biomarkers - blood
Blood pressure
Cardiac arrhythmia
Copeptin
Disease Progression
Follow-Up Studies
Glycopeptides - blood
Heart failure
Heart Failure - blood
Heart Failure - diagnosis
Heart rate
Hospitalization
Humans
Inpatients
Medical prognosis
Mortality
Natriuretic Peptide, Brain - blood
Original
Original s
Patients
Peptide Fragments - blood
Peptides
Prognosis
Prospective Studies
Protein Precursors
Serial measurement
Statistical analysis
Worsening heart failure
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Summary:Aims In heart failure, various biomarkers are established for diagnosis and risk stratification; however, little is known about the relevance of serial measurements during an episode worsening heart failure (WHF). This study sought to investigate the trajectory of natriuretic peptides and multiple novel biomarkers during hospitalization for WHF and to determine the best time point to predict outcome. Methods and results MOLITOR (Impact of Therapy Optimisation on the Level of Biomarkers in Patients with Acute and Decompensated Chronic Heart Failure) was an eight‐centre prospective study of 164 patients hospitalized with a primary diagnosis of WHF. C‐terminal fragment of pre‐pro‐vasopressin (copeptin), N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), mid‐regional pro‐atrial natriuretic peptide (MR‐proANP), mid‐regional pro‐adrenomedullin (MR‐proADM), and C‐terminal pro‐endothelin‐1 (CT‐proET1) were measured on admission, after 24, 48, and 72 h, and every 72 h thereafter, at discharge and follow‐up visits. Their performance to predict all‐cause mortality and rehospitalization at 90 days was compared. All biomarkers decreased during recompensation (P 
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.12231