Diagnostic Pathway of Oral Cavity Cancer in an Integrated Health Care System

• Published in: Permanente journal 2018-03, Vol.22 (2), p.17-152
• Main Authors: Wang, Kevin H, Song, Brian H, Gilde, Jason E, Darbinian, Jeanne A, Weintraub, Miranda L Ritterman, Wu, Tara J, Yang, Eleanor L, Salazar, James W, Gurushanthaiah, Deepak
• Format: Article
• Language: English
• Subjects: Age Factors; Aged; Alcohol Drinking - epidemiology; Continental Population Groups; Delivery of Health Care, Integrated; Dentists - statistics & numerical data; Female; Humans; Male; Middle Aged; Mouth Neoplasms - diagnosis; Mouth Neoplasms - epidemiology; Mouth Neoplasms - pathology; Neoplasm Staging; Original Research & Contributions; Referral and Consultation - statistics & numerical data; Retrospective Studies; Sex Factors; Smoking - epidemiology; Socioeconomic Factors; Squamous Cell Carcinoma of Head and Neck - diagnosis; Squamous Cell Carcinoma of Head and Neck - epidemiology; Squamous Cell Carcinoma of Head and Neck - pathology; Time-to-Treatment
• ISSN: 1552-5767; 1552-5775
• DOI: 10.7812/TPP/17-152

Survival for patients with oral cavity squamous cell carcinoma (OCSCC) has remained relatively stagnant despite advances in treatment. Few studies have examined why advanced-stage disease is diagnosed in 40% of patients with OCSCC nationally. To characterize the diagnostic pathway of OCSCC in an integrated health care system. Retrospective study of patients with OCSCC (2007-2010). Referral patterns and demographic, clinical, and tumor characteristics associated with time to diagnosis (diagnostic interval). Of 247 patients, 167 (68%) had early-stage (I/II) disease, 86 (35%) were referred by dentists, and 70 (28%) had a history of premalignancy. The median time (interquartile range) from symptom onset to care sought from a primary care physician (patient interval), from primary care physician to otolaryngologist, and from otolaryngologist to diagnosis was 8.6 (4.0-25.8), 1.0 (0.6-3.1), 0.0 (0.0-3.0) weeks, respectively. These intervals did not differ by demographic characteristics, clinical factors, or tumor stage. Prolonged diagnostic intervals were observed among patients with premalignant lesions. The patient interval was the largest component of the total diagnostic interval. The subsequent professional workup proceeded relatively efficiently. Prolonged diagnostic interval in patients with premalignant lesions may reflect the natural history of malignant transformation rather than a delay in diagnosis. However, nearly one-fourth of these cases were diagnosed at an advanced stage; closer surveillance may represent an opportunity for diagnosis at an earlier stage. Surveillance for premalignant lesions and facilitating referrals from dentists may expedite the diagnosis and treatment of OCSCC. Further investigation is warranted.