Disturbed retrieval network and prospective memory decline in postpartum women

Prospective memory (PM) refers to the ability to remember to execute an intended action in the future. For successful PM performance, both top-down strategic monitoring and bottom-up spontaneous retrieval processes need to be appropriately recruited. We assessed PM performance and used fMRI to disco...

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Bibliographic Details
Published in:Scientific reports 2018-04, Vol.8 (1), p.5476-11, Article 5476
Main Authors: Shin, Na-Young, Bak, Yunjin, Nah, Yoonjin, Han, Sanghoon, Kim, Dong Joon, Kim, Se Joo, Lee, Jong Eun, Lee, Sang-Guk, Lee, Seung-Koo
Format: Article
Language:English
Subjects:
17β-Estradiol
59/36
631/378/2649
692/1807/2782
Breastfeeding & lactation
Cognitive ability
Education
Functional magnetic resonance imaging
Hippocampus
Humanities and Social Sciences
Medical schools
Medicine
Memory
Mental depression
multidisciplinary
Postpartum
Questionnaires
Science
Science (multidisciplinary)
Sleep
University colleges
Womens health
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Summary:Prospective memory (PM) refers to the ability to remember to execute an intended action in the future. For successful PM performance, both top-down strategic monitoring and bottom-up spontaneous retrieval processes need to be appropriately recruited. We assessed PM performance and used fMRI to discover relevant neural correlates and possible predictors for PM performance in 25 postpartum and 26 nulliparous age- and education-matched women. Postpartum women showed decreased PM performance, a higher number of nocturnal awakenings, and lower estradiol level. The postpartum women had decreased functional connectivity (FC) in the right hippocampus and ventral frontoparietal networks (FPN) during retrieval-dominant PM trials relative to maintenance-dominant ongoing trials in the PM block. On multivariate analyses, decreased FC between the right hippocampus and ventral FPN and a higher number of nocturnal awakenings were independent predictors for poor PM performance after adjusting for age, education, estradiol level, and depressive symptoms. On mediation analyses, the estradiol level was found to have an indirect effect on PM accuracy via altered FC as a mediator. This suggests that decreased FC within the spontaneous retrieval-related regions including the right hippocampus and ventral FPN, disrupted sleep rhythms, and decreased estradiol level may contribute to poor PM performance in postpartum women.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-23875-5