Evaluation of biofilm formation on novel copper-catalyzed azide-alkyne cycloaddition (CuAAC)-based resins for dental restoratives

•Biofilm formation on the surface of CuAAC-based resins and composites was assessed.•A significant reduction in biofilm bioburden was observed on CuAAC-based materials.•Longevity of dental restorations that contain CuAAC-based materials may be enhanced. For the past several decades, the resins used...

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Bibliographic Details
Published in:Dental materials 2018-04, Vol.34 (4), p.657-666
Main Authors: Zajdowicz, Sheryl, Song, Han Byul, Baranek, Austin, Bowman, Christopher N.
Format: Article
Language:English
Subjects:
Alkynes
Alkynes - chemistry
Azides - chemistry
Bacteria
Biofilm
Biofilms
Biofilms - growth & development
Bisphenol A glycidyl methacrylate
Composite Resins - chemistry
Copper
Copper - chemistry
Copper-catalyzed azide-alkyne polymerization
Cycloaddition
Dental caries
Dental equipment
Dental materials
Dental Materials - chemistry
Dental resin composites
Dental restorative materials
Dentistry
Evaluation
Materials Testing
Monomers
Polymer matrix composites
Polymerization
Polymers
Reduction
Resins
Statistical analysis
Streptococcus mutans
Streptococcus mutans - growth & development
Surface Properties
Triethylene glycol dimethacrylate
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Summary:•Biofilm formation on the surface of CuAAC-based resins and composites was assessed.•A significant reduction in biofilm bioburden was observed on CuAAC-based materials.•Longevity of dental restorations that contain CuAAC-based materials may be enhanced. For the past several decades, the resins used in dental restorations have been plagued with numerous problems, including their implication in biofilm formation and secondary caries. The need for alternative resins is critical, and evaluation of biofilm formation on these resins is essential. The aim of this study was to evaluate in vitro biofilm formation on the surface of novel copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC)-based resins and composites. CuAAC-based resins/composites made from varying azide monomers and different copper concentrations were compared with BisGMA-TEGDMA resins/composites that served as the control. Biofilms were formed using a mono-species model containing a luciferase-expressing strain of Streptococcus mutans. Luciferase activity was measured and the number of viable bacteria was enumerated on biofilms associated with each resin and composite. A significant reduction (p
ISSN:0109-5641
1879-0097
DOI:10.1016/j.dental.2018.01.011