Leukocyte telomere length in relation to risk of lung adenocarcinoma incidence: Findings from the Singapore Chinese Health Study

Telomeres are crucial in the maintenance of chromosome integrity and genomic stability. Critically short telomeres can trigger programed cell death while cells with longer telomeres may have increased likelihood of replicative errors, resulting in genetic mutations and chromosomal alterations, and u...

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Bibliographic Details
Published in:International journal of cancer 2018-06, Vol.142 (11), p.2234-2243
Main Authors: Yuan, Jian‐Min, Beckman, Kenneth B., Wang, Renwei, Bull, Caroline, Adams‐Haduch, Jennifer, Huang, Joyce Y., Jin, Aizhen, Opresko, Patricia, Newman, Anne B., Zheng, Yun‐Ling, Fenech, Michael, Koh, Woon‐Puay
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - epidemiology
Adenocarcinoma - genetics
Aged
Cancer
Cell death
Female
Health risk assessment
Health risks
Humans
Incidence
Leukocytes
Leukocytes - metabolism
Lung cancer
Lung Neoplasms - epidemiology
Lung Neoplasms - genetics
Male
Medical research
Middle Aged
Mutation
Peripheral blood
Polymerase chain reaction
Proportional Hazards Models
Risk
Risk Assessment
Singapore - epidemiology
Squamous cell carcinoma
Studies
Telomerase
Telomere - genetics
Telomere Homeostasis
Telomeres
Tumorigenesis
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Summary:Telomeres are crucial in the maintenance of chromosome integrity and genomic stability. Critically short telomeres can trigger programed cell death while cells with longer telomeres may have increased likelihood of replicative errors, resulting in genetic mutations and chromosomal alterations, and ultimately promoting oncogenesis. Data on telomere length and lung cancer risk from large prospective cohort studies are spare. Relative telomere length in peripheral blood leukocytes was quantified using a validated monochrome multiplex quantitative polymerase chain reaction (qPCR) method in 26,540 participants of the Singapore Chinese Health Study. After a follow‐up of 12 years, 654 participants developed lung cancer including 288 adenocarcinoma, 113 squamous cell carcinoma and 253 other/unknown histological type. The Cox proportional hazard regression was used to estimate hazard ratio (HR) and 95% confidence interval (CI). HR of lung adenocarcinoma for individuals in the highest comparing the lowest 20 percentile of telomere length was 2.84 (95% CI 1.94–4.14, ptrend 
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.31251