The effect of task difficulty on motor performance and frontal-striatal connectivity in cocaine users

Highlights • Cocaine users are consistently less accurate on basic finger-tapping tasks. • They have lower frontal-striatal connectivity during all levels of task difficulty. • As task difficulty increases, both controls and cocaine users make more errors. • However, network connectivity degrades wi...

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Bibliographic Details
Published in:Drug and alcohol dependence 2017-04, Vol.173, p.178-184
Main Authors: Lench, Daniel H, DeVries, William, Hanlon, Colleen A
Format: Article
Language:English
Subjects:
Addiction
Adult
Attention - drug effects
Attention - physiology
Cerebellum
Cerebellum - drug effects
Cerebellum - physiopathology
Circuits
Cocaine
Cocaine - toxicity
Cocaine-Related Disorders - physiopathology
Cocaine-Related Disorders - psychology
Cognition & reasoning
Cognitive
Cognitive ability
Connectivity
Corpus Striatum - drug effects
Corpus Striatum - physiopathology
Cortex
Cortex (cingulate)
Cortex (motor)
Drug abuse
Drug addiction
Drug use
Female
Frontal Lobe - drug effects
Frontal Lobe - physiopathology
Functional connectivity
Functional magnetic resonance imaging
Gyrus Cinguli - drug effects
Gyrus Cinguli - physiopathology
Help seeking behavior
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Motor ability
Motor Cortex - physiopathology
Motor task performance
Neostriatum
Nerve Net - drug effects
Nerve Net - physiopathology
Neural networks
Neuroimaging
Psychiatry
Psychomotor Performance - drug effects
Psychomotor Performance - physiology
Putamen
Putamen - drug effects
Putamen - physiopathology
Sensorimotor
Sensorimotor performance
Sensorimotor system
Supplementary motor area
Task performance
Temporal cortex
Young Adult
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Description
Summary:Highlights • Cocaine users are consistently less accurate on basic finger-tapping tasks. • They have lower frontal-striatal connectivity during all levels of task difficulty. • As task difficulty increases, both controls and cocaine users make more errors. • However, network connectivity degrades with difficulty in users but not controls.
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2016.12.008