A protocol for a Canadian prospective observational study of decision-making on active surveillance or surgery for low-risk papillary thyroid cancer

IntroductionLow-risk papillary thyroid cancer (PTC) is increasingly being diagnosed throughout the world; yet the mortality risk is low compared with other malignancies. Traditional management includes thyroid surgery, sometimes followed by radioactive iodine and thyroid hormone treatment. Active su...

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Bibliographic Details
Published in:BMJ open 2018-04, Vol.8 (4), p.e020298-e020298
Main Authors: Sawka, Anna M, Ghai, Sangeet, Tomlinson, George, Rotstein, Lorne, Gilbert, Ralph, Gullane, Patrick, Pasternak, Jesse, Brown, Dale, de Almeida, John, Irish, Jonathan, Chepeha, Douglas, Higgins, Kevin, Monteiro, Eric, Jones, Jennifer M, Gafni, Amiram, Goldstein, David P
Format: Article
Language:English
Subjects:
Adenocarcinoma, Papillary - surgery
Adenocarcinoma, Papillary - therapy
Adult
Canada
Clinical decision making
Clinical Protocols
Decision Making
Health surveillance
Hospitals
Humans
Iodine
Metastasis
Neuroendocrine tumors
Observational studies
Oncology
Patient satisfaction
Prospective Studies
Quality of Life
Questionnaires
Research Design
Self image
Surgery
Thyroid cancer
Thyroid Neoplasms - surgery
Thyroid Neoplasms - therapy
Watchful Waiting
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Summary:IntroductionLow-risk papillary thyroid cancer (PTC) is increasingly being diagnosed throughout the world; yet the mortality risk is low compared with other malignancies. Traditional management includes thyroid surgery, sometimes followed by radioactive iodine and thyroid hormone treatment. Active surveillance (AS) has been proposed as a means to reduce overtreatment of PTC. AS involves close disease follow-up, with the intention to intervene if the disease progresses, or on patient request.Methods and analysisThis is a multiphase prospective observational study. In the first phase of this study, consenting eligible adults with low-risk PTC, that is,
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2017-020298