Effects of Composite Supplement Containing Astaxanthin and Sesamin on Cognitive Functions in People with Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Trial

Background: Dementia and its first or transitional stage, mild cognitive impairment (MCI), is a major concern for the aging Japanese society. Thus, the use of dietary supplements to improve or maintain cognitive function has become a topic of public interest. Objective: In this study, we evaluated t...

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Bibliographic Details
Published in:Journal of Alzheimer's disease 2018-01, Vol.62 (4), p.1767-1775
Main Authors: Ito, Naoki, Saito, Hitomi, Seki, Shinobu, Ueda, Fumitaka, Asada, Takashi
Format: Article
Language:English
Subjects:
Aged
Aging
Alzheimer's disease
Antioxidants
Astaxanthin
Central nervous system
Cognitive ability
Cognitive Dysfunction - therapy
Dementia disorders
Diet
Dietary Supplements
Dioxoles - therapeutic use
Double-Blind Method
Double-blind studies
Female
Food composition
Humans
Impairment
Lignans - therapeutic use
Male
Middle Aged
Neuropsychological Tests
Pilot Projects
Psychomotor performance
Public concern
Task complexity
Treatment Outcome
Xanthophylls - therapeutic use
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Summary:Background: Dementia and its first or transitional stage, mild cognitive impairment (MCI), is a major concern for the aging Japanese society. Thus, the use of dietary supplements to improve or maintain cognitive function has become a topic of public interest. Objective: In this study, we evaluated the effects of a composite supplement containing food-derived antioxidants, specifically astaxanthin and sesamin (AS), on cognitive function in people with MCI. Method: Twenty-one healthy participants with MCI were recruited in our double-blind placebo-controlled pilot study. They were assigned to either an AS group, who received ingestible capsules containing AS, or a placebo group, who received identical placebo capsules. To assess cognitive functions, we performed the Japanese version of the Central Nervous System Vital Signs (CNSVS) test and the Alzheimer’s Disease Assessment Scale-Cog test at baseline, after 6 weeks, and after 12 weeks of dietary supplementation. Results: The CNSVS test revealed significant improvements in psychomotor speed and processing speed in the AS group compared with the placebo group, suggesting that the daily supplementation of AS improved cognitive functions related to the ability to comprehend, and perform complex tasks quickly and accurately. Conclusion: Our results provide support for the use of AS as a dietary supplementation for improving cognitive functions.
ISSN:1387-2877
1875-8908
DOI:10.3233/JAD-170969