Evaluating Vitamin D Status in Pre- and Postmenopausal Type 2 Diabetics and Its Association with Glucose Homeostasis

Background. Type 2 Diabetes Mellitus (T2DM) and menopause are associated with vitamin D status. Oestrogen decline during menopausal stages promotes hypovitaminosis D. However, the interplay between vitamin D, menopause, lifestyle, and T2DM cannot be overlooked. This study assessed vitamin D status a...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2018-01, Vol.2018 (2018), p.1-12
Main Authors: Kantanka, Osei Sarfo, Awusi, Ebenezer Kwesi, Owiredu, Eddie-Williams, Laing, Edwin F., Owiredu, William K. B. A., Sakyi, Samuel A., Fondjo, Linda Ahenkorah, Ephraim, Richard K. D.
Format: Article
Language:English
Subjects:
Alfacalcidol
Analysis
Blood glucose
Blood Pressure
Blood sugar
Body Mass Index
Calcifediol
Calcium
Clinical medicine
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - metabolism
Diabetes therapy
Diabetics
Diet therapy
Endocrinology
Enzyme-linked immunosorbent assay
Estrogen
Estrogens
Ethylenediaminetetraacetic acid
Family medical history
Ghana
Glucose
Glycosylated hemoglobin
Hemoglobin
Homeostasis
Humans
Hypertension
Insulin
Insulin resistance
Lifestyles
Lipids - blood
Menopause
Metabolism
Nutrient deficiency
Osteoporosis
Post-menopause
Postmenopausal women
Postmenopause - blood
Public health
R&D
Research & development
Statistical analysis
Statistical methods
Studies
Teaching hospitals
Teaching methods
Type 2 diabetes
Vitamin D
Vitamin D - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - epidemiology
Vitamin deficiency
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. Type 2 Diabetes Mellitus (T2DM) and menopause are associated with vitamin D status. Oestrogen decline during menopausal stages promotes hypovitaminosis D. However, the interplay between vitamin D, menopause, lifestyle, and T2DM cannot be overlooked. This study assessed vitamin D status among pre- and postmenopausal T2DM women and determined its association with glycemic control and influence of lifestyle habits on hypovitaminosis D. Methods. This cross-sectional study was conducted at the Komfo Anokye Teaching Hospital, Kumasi, Ghana. Structured questionnaires were administered to 192 T2DM women; blood samples were collected for estimation of 25(OH) D and insulin using ELISA. Fasting blood glucose (FBG), lipid profile, glycated haemoglobin (HbA1c), and calcium were measured. Statistical analyses were performed using Graphpad Prism 6. Results. The prevalence of vitamin D inadequacy was 92.2%. Hypovitaminosis D was more prevalent among the postmenopausal T2DM women (63.8% versus 58.2%). Hypovitaminosis D significantly associated with insulin [R2=0.01760, p=0.0008], HbA1c [R2=0.3709, p=
ISSN:2314-6133
2314-6141
DOI:10.1155/2018/9369282