Alternative strategies to in vitro fertilization/intracytoplasmic sperm injection treatment for aged infertile women

Purpose This study aimed to maximize the chance of pregnancy and provide an optimal protocol for infertile female patients of advanced reproductive age as an alternative to in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment. Methods We retrospectively analyzed medical rec...

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Bibliographic Details
Published in:Reproductive medicine and biology 2012-01, Vol.11 (1), p.69-72
Main Authors: Isono, Wataru, Wada-Hiraike, Osamu, Shirane, Akira, Fujimoto, Akihisa, Osuga, Yutaka, Yano, Tetsu, Taketani, Yuji
Format: Article
Language:English
Subjects:
Advanced reproductive age
Age
Clinical pregnancy rate
Endometriosis
Fertility
Gynecology
ICSI
In vitro fertilization
Infertility
IVF
Medical records
Medicine
Medicine & Public Health
Original
Original Article
Ovulation
Patients
Pregnancy
Reproductive Medicine
Reproductive technologies
Sperm
Urology
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Summary:Purpose This study aimed to maximize the chance of pregnancy and provide an optimal protocol for infertile female patients of advanced reproductive age as an alternative to in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment. Methods We retrospectively analyzed medical records of 432 infertile women aged ≥38 at the beginning of the treatment. Stepwise non-IVF/ICSI treatments using timed intercourse or intrauterine insemination, with or without controlled ovarian stimulation, were adopted for all patients. In this population, we extracted 8 representative infertility factors and examined these effects on fertility rate by calculating clinical pregnancy rate. Results The prognosis for infertile women possessing at least one of the three factors, ‘advanced female age (≥42 years)’, ‘endometriosis/adenomyosis’, and ‘tubal infertility’ was apparently poor because only 5 out of 155 women were able to conceive (1.02% per cycle). In contrast, 95 patients without the four factors, ‘advanced female age’, ‘endometriosis/adenomyosis’, ‘tubal infertility’, and ‘male infertility’, were more likely to conceive (9.14% per cycle). Conclusions Fertility centers can offer appropriate protocols for non-IVF/ICSI treatment and establish guidelines for aged infertile patients by examining infertility factors and considering their combinations.
ISSN:1445-5781
1447-0578
DOI:10.1007/s12522-011-0107-4