Impact of the malaria parasite on reproductive indices of male mice

Aim:  To investigate the impact and possible mechanism of action of the rodent malarial parasite on reproduction. Methods:  Male albino mice were infected with 15, 30 and 45%Plasmodium berghei berghei through inoculation with 107 parasitized red blood cells. Each experiment had its own control that...

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Bibliographic Details
Published in:Reproductive medicine and biology 2006-09, Vol.5 (3), p.201-209
Main Authors: RAJI, YINUSA, AKINSOMISOYE, OLUMIDE S., AZEEZ, MISTURA O.
Format: Article
Language:English
Subjects:
Andrology
Antiparasitic agents
Cell size
Drug resistance
Erythrocytes
Fertility
Infections
Infertility
Inoculation
Leukocytes
Malaria
male
mice
Parasites
Plasmodium
reproduction
Sperm
Testosterone
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Summary:Aim:  To investigate the impact and possible mechanism of action of the rodent malarial parasite on reproduction. Methods:  Male albino mice were infected with 15, 30 and 45%Plasmodium berghei berghei through inoculation with 107 parasitized red blood cells. Each experiment had its own control that was not infected with P. berghei berghei. Mice infected with 15%P. berghei berghei were killed on days 0, 5, 10 and 15; those infected with 30%P. berghei berghei were killed on days 0, 3, 6 and 10; and those infected with 45%P. berghei berghei were killed on days 1–7 after infection. Caudal epididymal sperm motility, counts and morphology, body and wet organ weights and hematological indices were determined. Results:  The results showed a progressive duration dependent decrease in sperm motility, sperm count and viability (P 
ISSN:1445-5781
1447-0578
DOI:10.1111/j.1447-0578.2006.00142.x