Effects of Saireito on the ovarian function of patients with polycystic ovary syndrome

Purposes It is sometimes difficult to restore a regular ovulatory cycle in women with polycystic ovary syndrome (PCOS) using classic agents such as clomiphene citrate or gonadotropins. Saireito, a herbal medicine, is believed to have an effect similar to corticosteroids. We examined the effect of Sa...

Full description

Saved in:
Bibliographic Details
Published in:Reproductive medicine and biology 2010-12, Vol.9 (4), p.191-195
Main Authors: Okamoto, Machi, Sakakibara, Hideya, Yoshida, Hiroshi, Fukazawa, Yuka, Takashima, Kunitomo, Kondo, Yoshihito, Ikeda, Mario, Ishikawa, Masahiko, Hirahara, Fumiki
Format: Article
Language:English
Subjects:
17β-Estradiol
Adrenocorticotropic hormone
Breast cancer
Clomiphene
Corticosteroids
Endocrinology
Follicle-stimulating hormone
Gonadotropins
Gynecology
Herbal medicine
Hydrocortisone
Luteinizing hormone
Medicine
Medicine & Public Health
Obstetrics
Original
Original Article
Ovaries
Ovulation
Ovulatory induction
Pituitary (anterior)
Polycystic ovary syndrome
Prolactin
Reproductive Medicine
Reproductive status
Saireito
Testosterone
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purposes It is sometimes difficult to restore a regular ovulatory cycle in women with polycystic ovary syndrome (PCOS) using classic agents such as clomiphene citrate or gonadotropins. Saireito, a herbal medicine, is believed to have an effect similar to corticosteroids. We examined the effect of Saireito on ovulatory induction and endocrine status in women with PCOS. Methods Twenty-four women with PCOS were treated with Saireito for 3 months. Serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), testosterone (T), estradiol (E 2 ), adrenocorticotropic hormone (ACTH), and cortisol were measured before and after treatment, and ovulation was assessed. We compared serum LH levels between ovulation ( n  = 21) and anovulation ( n  = 3) groups, and compared ovulation rate and serum LH levels between obese ( n  = 6) and nonobese ( n  = 18) groups. Results Ovulation was restored in 21 (87.5%) of the 24 PCOS patients following administration of Saireito for 3 months. LH levels were significantly decreased 1 month after medication in ovulatory group ( P  
ISSN:1445-5781
1447-0578
DOI:10.1007/s12522-010-0057-2