Retrospective Analysis of Posaconazole Suspension Dosing Strategies in a Pediatric Oncology Population: Single-Center Experience

Abstract Limited data on optimal posaconazole dosing strategies for pediatric patients exist. In this study, we found that the median initial dose in patients who achieved a posaconazole plasma concentration of 0.7 μg/mL was 22.8 mg/kg per day whereas the median initial dose in those who did not rea...

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Bibliographic Details
Published in:Journal of the Pediatric Infectious Diseases Society 2017-09, Vol.6 (3), p.e149-e151
Main Authors: Mathew, Sherry, Kussin, Michelle L, Liu, Dazhi, Pozotrigo, Melissa, Seyboth, Brian, Thackray, Jennifer, Yan, Shirley Qiong, Hsu, Meier, Cohen, Nina, Seo, Susan K
Format: Article
Language:English
Subjects:
Adolescent
Antifungal Agents - administration & dosage
Antifungal Agents - blood
Antifungal Agents - therapeutic use
Child
Child, Preschool
Drug Administration Schedule
Electronic
Female
Humans
Male
Neoplasms - complications
Retrospective Studies
Suspensions
Triazoles - administration & dosage
Triazoles - blood
Triazoles - therapeutic use
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Summary:Abstract Limited data on optimal posaconazole dosing strategies for pediatric patients exist. In this study, we found that the median initial dose in patients who achieved a posaconazole plasma concentration of 0.7 μg/mL was 22.8 mg/kg per day whereas the median initial dose in those who did not reach the target concentration was 15.8 mg/kg per day; this result suggests that higher initial doses might be warranted.
ISSN:2048-7193
2048-7207
DOI:10.1093/jpids/pix058