Membrane bending by actin polymerization

Actin polymerization provides driving force to aid several types of processes that involve pulling the plasma membrane into the cell, including phagocytosis, cellular entry of large viruses, and endocytosis. In endocytosis, actin polymerization is especially important under conditions of high membra...

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Bibliographic Details
Published in:Current opinion in cell biology 2018-02, Vol.50, p.1-7
Main Author: Carlsson, Anders E
Format: Article
Language:English
Subjects:
Actins - chemistry
Actins - metabolism
Animals
Cell Membrane - chemistry
Cell Membrane - metabolism
Endocytosis
Polymerization
Yeasts - chemistry
Yeasts - cytology
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Summary:Actin polymerization provides driving force to aid several types of processes that involve pulling the plasma membrane into the cell, including phagocytosis, cellular entry of large viruses, and endocytosis. In endocytosis, actin polymerization is especially important under conditions of high membrane tension or high turgor pressure. Recent modeling efforts have shown how actin polymerization can give rise to a distribution of forces around the endocytic site, and explored how these forces affect the shape dynamics; experiments have revealed the structure of the endocytic machinery in increasing detail, and demonstrated key feedback interactions between actin assembly and membrane curvature. Here we provide a perspective on these findings and suggest avenues for future research.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2017.11.007