Treatment patterns and low-density lipoprotein cholesterol (LDL-C) goal attainment among patients receiving high- or moderate-intensity statins

Background European clinical guidelines recommend a low-density lipoprotein cholesterol (LDL-C) goal of  2 million individuals annually) to identify ASCVD (coronary atherosclerosis, stable/unstable angina, myocardial infarction, ischemic stroke, transient ischemic attack, aneurysm, peripheral artery...

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Bibliographic Details
Published in:Clinical research in cardiology 2018-05, Vol.107 (5), p.380-388
Main Authors: Fox, Kathleen M., Tai, Ming-Hui, Kostev, Karel, Hatz, Maximilian, Qian, Yi, Laufs, Ulrich
Format: Article
Language:English
Subjects:
Angina
Arteriosclerosis
Atherosclerosis
Cardiology
Cerebral infarction
Cholesterol
Electronic health records
Electronic medical records
Ischemia
Low density lipoprotein
Medicine
Medicine & Public Health
Myocardial infarction
Original Paper
Patients
Statins
Titration
Transient ischemic attack
Vascular diseases
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Summary:Background European clinical guidelines recommend a low-density lipoprotein cholesterol (LDL-C) goal of  2 million individuals annually) to identify ASCVD (coronary atherosclerosis, stable/unstable angina, myocardial infarction, ischemic stroke, transient ischemic attack, aneurysm, peripheral artery disease) patients on moderate-/high-intensity statin in Germany. Proportion of patients with LDL-C  14,000 patients assessed in each year (mean age 71 years, 35% female, 8–12% taking high-intensity statins), approximately 80% had LDL-C ≥ 70 mg/dL. Treatment patterns were assessed for most (88–93%) patients. Approximately 79–81% of patients made no change to statin regimens, 1% switched statins, 14–16% discontinued; 1% of moderate-intensity patients up-titrated, and 3% of all patients down-titrated. LDL-C goal attainment in these treatment pattern groups was 20, 16–24, 17, 11–14, and 17–19%, respectively. Conclusions Majority of ASCVD patients had LDL-C ≥ 70 mg/dL while on moderate-/high-intensity statins. Despite low LDL-C goal attainment, few patients changed their treatment regimens.
ISSN:1861-0684
1861-0692
DOI:10.1007/s00392-017-1193-z