A study on association of iron deficiency with attention deficit hyperactivity disorder in a tertiary care center

Background: Iron is important for brain development and cognitive function. Iron deficiency may cause alteration of neurotransmitters and may be manifested by different central nervous system disorders including attention deficit hyperactivity disorder (ADHD). Aims: As studies are scarce in the Indi...

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Bibliographic Details
Published in:Indian journal of psychiatry 2018-01, Vol.60 (1), p.131-134
Main Authors: Islam, Kamirul, Seth, Soutrik, Saha, Suman, Roy, Atanu, Das, Rajib, Datta, Asok
Format: Article
Language:English
Subjects:
Age
Anemia
Attention deficit hyperactivity disorder
Brief Research Communication
Central nervous system
Cognitive ability
Confidence intervals
Dopamine
Enumeration
Ferritin
Hemoglobin
Hyperactivity
Iron
Iron deficiency
Iron deficiency diseases
Laboratories
Mental disorders
Neurotransmitters
Nutrient deficiency
Pediatrics
Psychiatry
Restless legs syndrome
Risk factors
Statistical analysis
Teenagers
Variables
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Summary:Background: Iron is important for brain development and cognitive function. Iron deficiency may cause alteration of neurotransmitters and may be manifested by different central nervous system disorders including attention deficit hyperactivity disorder (ADHD). Aims: As studies are scarce in the Indian context, we had undertaken this study to find out the association between iron deficiency and ADHD. Settings and Design: Hospital-based cross-sectional study. Materials and Methods: Hematological parameters indicating iron status (hemoglobin [Hb], ferritin, Iron, total iron binding capacity [TIBC], mean corpuscular volume [MCV], and mean corpuscular Hb [MCH]) were measured among 119 ADHD patients selected by complete enumeration method and 119 controls. Statistical Analysis: Shapiro-Wilk test, Mann-Whitney U-test, Spearman's correlation, and binary logistic regression were used. P < 0.01 was taken as statistically significant. Results: Hb, iron, ferritin, MCV, and MCH were lower among cases and negatively correlated to ADHD, while reverse is true for TIBC and ADHD. Iron deficiency anemia makes one 3.82 times more prone for ADHD. Conclusion: Iron deficiency was associated with ADHD.
ISSN:0019-5545
1998-3794
DOI:10.4103/psychiatry.IndianJPsychiatry_197_17