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A study on association of iron deficiency with attention deficit hyperactivity disorder in a tertiary care center
Background: Iron is important for brain development and cognitive function. Iron deficiency may cause alteration of neurotransmitters and may be manifested by different central nervous system disorders including attention deficit hyperactivity disorder (ADHD). Aims: As studies are scarce in the Indi...
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| Published in: | Indian journal of psychiatry 2018-01, Vol.60 (1), p.131-134 |
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| Main Authors: | , , , , , |
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| container_end_page | 134 |
| container_issue | 1 |
| container_start_page | 131 |
| container_title | Indian journal of psychiatry |
| container_volume | 60 |
| creator | Islam, Kamirul Seth, Soutrik Saha, Suman Roy, Atanu Das, Rajib Datta, Asok |
| description | Background: Iron is important for brain development and cognitive function. Iron deficiency may cause alteration of neurotransmitters and may be manifested by different central nervous system disorders including attention deficit hyperactivity disorder (ADHD).
Aims: As studies are scarce in the Indian context, we had undertaken this study to find out the association between iron deficiency and ADHD.
Settings and Design: Hospital-based cross-sectional study.
Materials and Methods: Hematological parameters indicating iron status (hemoglobin [Hb], ferritin, Iron, total iron binding capacity [TIBC], mean corpuscular volume [MCV], and mean corpuscular Hb [MCH]) were measured among 119 ADHD patients selected by complete enumeration method and 119 controls.
Statistical Analysis: Shapiro-Wilk test, Mann-Whitney U-test, Spearman's correlation, and binary logistic regression were used. P < 0.01 was taken as statistically significant.
Results: Hb, iron, ferritin, MCV, and MCH were lower among cases and negatively correlated to ADHD, while reverse is true for TIBC and ADHD. Iron deficiency anemia makes one 3.82 times more prone for ADHD.
Conclusion: Iron deficiency was associated with ADHD. |
| doi_str_mv | 10.4103/psychiatry.IndianJPsychiatry_197_17 |
| format | article |
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Aims: As studies are scarce in the Indian context, we had undertaken this study to find out the association between iron deficiency and ADHD.
Settings and Design: Hospital-based cross-sectional study.
Materials and Methods: Hematological parameters indicating iron status (hemoglobin [Hb], ferritin, Iron, total iron binding capacity [TIBC], mean corpuscular volume [MCV], and mean corpuscular Hb [MCH]) were measured among 119 ADHD patients selected by complete enumeration method and 119 controls.
Statistical Analysis: Shapiro-Wilk test, Mann-Whitney U-test, Spearman's correlation, and binary logistic regression were used. P < 0.01 was taken as statistically significant.
Results: Hb, iron, ferritin, MCV, and MCH were lower among cases and negatively correlated to ADHD, while reverse is true for TIBC and ADHD. Iron deficiency anemia makes one 3.82 times more prone for ADHD.
Conclusion: Iron deficiency was associated with ADHD.</description><identifier>ISSN: 0019-5545</identifier><identifier>EISSN: 1998-3794</identifier><identifier>DOI: 10.4103/psychiatry.IndianJPsychiatry_197_17</identifier><identifier>PMID: 29736076</identifier><language>eng</language><publisher>India: Wolters Kluwer India Pvt. Ltd</publisher><subject>Age ; Anemia ; Attention deficit hyperactivity disorder ; Brief Research Communication ; Central nervous system ; Cognitive ability ; Confidence intervals ; Dopamine ; Enumeration ; Ferritin ; Hemoglobin ; Hyperactivity ; Iron ; Iron deficiency ; Iron deficiency diseases ; Laboratories ; Mental disorders ; Neurotransmitters ; Nutrient deficiency ; Pediatrics ; Psychiatry ; Restless legs syndrome ; Risk factors ; Statistical analysis ; Teenagers ; Variables</subject><ispartof>Indian journal of psychiatry, 2018-01, Vol.60 (1), p.131-134</ispartof><rights>COPYRIGHT 2018 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt. Ltd. Jan/Mar 2018</rights><rights>Copyright: © 2018 Indian Journal of Psychiatry 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c668t-b597e3e30000ac5a140b23f7088ab43d49e11a11e2a53c3f7f8cf0cfa2f0f9d73</citedby><cites>FETCH-LOGICAL-c668t-b597e3e30000ac5a140b23f7088ab43d49e11a11e2a53c3f7f8cf0cfa2f0f9d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914242/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2025630219?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4009,25732,27437,27902,27903,27904,36991,36992,44569,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29736076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Islam, Kamirul</creatorcontrib><creatorcontrib>Seth, Soutrik</creatorcontrib><creatorcontrib>Saha, Suman</creatorcontrib><creatorcontrib>Roy, Atanu</creatorcontrib><creatorcontrib>Das, Rajib</creatorcontrib><creatorcontrib>Datta, Asok</creatorcontrib><title>A study on association of iron deficiency with attention deficit hyperactivity disorder in a tertiary care center</title><title>Indian journal of psychiatry</title><addtitle>Indian J Psychiatry</addtitle><description>Background: Iron is important for brain development and cognitive function. Iron deficiency may cause alteration of neurotransmitters and may be manifested by different central nervous system disorders including attention deficit hyperactivity disorder (ADHD).
Aims: As studies are scarce in the Indian context, we had undertaken this study to find out the association between iron deficiency and ADHD.
Settings and Design: Hospital-based cross-sectional study.
Materials and Methods: Hematological parameters indicating iron status (hemoglobin [Hb], ferritin, Iron, total iron binding capacity [TIBC], mean corpuscular volume [MCV], and mean corpuscular Hb [MCH]) were measured among 119 ADHD patients selected by complete enumeration method and 119 controls.
Statistical Analysis: Shapiro-Wilk test, Mann-Whitney U-test, Spearman's correlation, and binary logistic regression were used. P < 0.01 was taken as statistically significant.
Results: Hb, iron, ferritin, MCV, and MCH were lower among cases and negatively correlated to ADHD, while reverse is true for TIBC and ADHD. Iron deficiency anemia makes one 3.82 times more prone for ADHD.
Conclusion: Iron deficiency was associated with ADHD.</description><subject>Age</subject><subject>Anemia</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Brief Research Communication</subject><subject>Central nervous system</subject><subject>Cognitive ability</subject><subject>Confidence intervals</subject><subject>Dopamine</subject><subject>Enumeration</subject><subject>Ferritin</subject><subject>Hemoglobin</subject><subject>Hyperactivity</subject><subject>Iron</subject><subject>Iron deficiency</subject><subject>Iron deficiency diseases</subject><subject>Laboratories</subject><subject>Mental disorders</subject><subject>Neurotransmitters</subject><subject>Nutrient deficiency</subject><subject>Pediatrics</subject><subject>Psychiatry</subject><subject>Restless legs syndrome</subject><subject>Risk factors</subject><subject>Statistical analysis</subject><subject>Teenagers</subject><subject>Variables</subject><issn>0019-5545</issn><issn>1998-3794</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqVkk1vEzEQhlcIRNPCX0CWkFAllOCv_fAFKYqgFFWCA5yN4x133W7s1PY22n-P07Rpg-CAfbDleeYde_wWxXuCZ5xg9mEdR91ZlcI4O3etVe7r9_2JJKKWpH5WTIgQzZTVgj8vJhgTMS1LXh4VxzFeYUwrXtYviyMqalbhupoUN3MU09COyDukYvQ6y9m89wbZkNcWjNUWnB7RxqYOqZTA3RG7SELduIagdLK3No2otdGHFgKyWQ8lCMmqMCKtAiCdMyG8Kl4Y1Ud4fb-eFD8_f_qx-DK9-HZ2vphfTHVVNWm6LEUNDBjOQ-lSEY6XlJkaN41actZyAYQoQoCqkukcMI02WBtFDTairdlJ8XGnux6WK2i3xYPq5TrYVb6R9MrKw4iznbz0t7IUhFNOs8DpvUDwNwPEJFc2auh75cAPUVLMKorLhjcZffsHeuWH4PLzMkXLimFKxCN1qXqQ1hmf6-qtqJyXjAvSYMEyNfsLlWcLK6u9y23P5wcJ754kdKD61EXfD9tfiofgYgfq4GMMYPbNIFhuLSYfLSb_ZbGs8uZpX_caD57KwK8dsPF9_u943Q8bCDKz185v_qeWJIzIubwzqPROPhiU_QaVYf0K</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Islam, Kamirul</creator><creator>Seth, Soutrik</creator><creator>Saha, Suman</creator><creator>Roy, Atanu</creator><creator>Das, Rajib</creator><creator>Datta, Asok</creator><general>Wolters Kluwer India Pvt. 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Iron deficiency may cause alteration of neurotransmitters and may be manifested by different central nervous system disorders including attention deficit hyperactivity disorder (ADHD).
Aims: As studies are scarce in the Indian context, we had undertaken this study to find out the association between iron deficiency and ADHD.
Settings and Design: Hospital-based cross-sectional study.
Materials and Methods: Hematological parameters indicating iron status (hemoglobin [Hb], ferritin, Iron, total iron binding capacity [TIBC], mean corpuscular volume [MCV], and mean corpuscular Hb [MCH]) were measured among 119 ADHD patients selected by complete enumeration method and 119 controls.
Statistical Analysis: Shapiro-Wilk test, Mann-Whitney U-test, Spearman's correlation, and binary logistic regression were used. P < 0.01 was taken as statistically significant.
Results: Hb, iron, ferritin, MCV, and MCH were lower among cases and negatively correlated to ADHD, while reverse is true for TIBC and ADHD. Iron deficiency anemia makes one 3.82 times more prone for ADHD.
Conclusion: Iron deficiency was associated with ADHD.</abstract><cop>India</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>29736076</pmid><doi>10.4103/psychiatry.IndianJPsychiatry_197_17</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0019-5545 |
| ispartof | Indian journal of psychiatry, 2018-01, Vol.60 (1), p.131-134 |
| issn | 0019-5545 1998-3794 |
| language | eng |
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| source | Medknow Open Access Medical Journals(OpenAccess); Publicly Available Content Database; PubMed Central |
| subjects | Age Anemia Attention deficit hyperactivity disorder Brief Research Communication Central nervous system Cognitive ability Confidence intervals Dopamine Enumeration Ferritin Hemoglobin Hyperactivity Iron Iron deficiency Iron deficiency diseases Laboratories Mental disorders Neurotransmitters Nutrient deficiency Pediatrics Psychiatry Restless legs syndrome Risk factors Statistical analysis Teenagers Variables |
| title | A study on association of iron deficiency with attention deficit hyperactivity disorder in a tertiary care center |
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