Pepsinogens I and II in Gastric Cancer: An Immunohistochemical Study Using Monoclonal Antibodies

Monoclonal antibodies were used to examine the immunohistochemical expression of pepsinogens I and II in 31 early and 76 advanced gastric cancers. Of the 107 carcinomas studied, 19 contained pepsinogen II and only 3, found exclusively in pepsinogen II‐positive cases, contained pepsinogen I. Gastric...

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Published in:Cancer science 1988-10, Vol.79 (10), p.1139-1146
Main Authors: Huang, Shih Che, Miki, Kazumasa, Sano, Junjiro, Ichinose, Masao, Kawamura, Norio, Oka, Hiroshi, Hirano, Kazuyuki, Furihata, Chie, Masugi, Yozo, Takahashi, Kenji
Format: Article
Language:English
Subjects:
Aged
Antibodies, Monoclonal
Biological and medical sciences
Carcinoma
Female
Gastric cancer
Gastric Mucosa - enzymology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunohistochemistry
Intestine
Lymph nodes
Lymphatic Metastasis
Male
Medical sciences
Metastases
Middle Aged
Monoclonal antibodies
Monoclonal antibody
Pepsinogen
Pepsinogens - analysis
Stomach Neoplasms - enzymology
Stomach Neoplasms - pathology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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cited_by cdi_FETCH-LOGICAL-c5159-1f05e5f3cf649c2804b49d30f30f6e86314f23fa8438a1e579e7600d9ef460753
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container_end_page 1146
container_issue 10
container_start_page 1139
container_title Cancer science
container_volume 79
creator Huang, Shih Che
Miki, Kazumasa
Sano, Junjiro
Ichinose, Masao
Kawamura, Norio
Oka, Hiroshi
Hirano, Kazuyuki
Furihata, Chie
Masugi, Yozo
Takahashi, Kenji
description Monoclonal antibodies were used to examine the immunohistochemical expression of pepsinogens I and II in 31 early and 76 advanced gastric cancers. Of the 107 carcinomas studied, 19 contained pepsinogen II and only 3, found exclusively in pepsinogen II‐positive cases, contained pepsinogen I. Gastric cancer produces pepsinogen II more frequently than pepsinogen I, and production of the latter is significantly associated with the former. Historically, there were 54 intestinal‐type and 53 diffuse‐type cancers. The former produced pepsinogen II more frequently than the latter. In the diffuse type, the four pepsinogen II‐positive cases were found exclusively in females. Although the pepsinogen expression was independent of the macroscopic features in advanced gastric cancer, it was found that the protruded‐type early gastric cancer produced pepsinogen II more frequently than the depressed type. Incidences of pepsinogen positivity were not different between early and advanced gastric cancers or between cancers with or without lymph node metastasis, suggesting that production of pepsinogen is independent of tumor growth.
doi_str_mv 10.1111/j.1349-7006.1988.tb01537.x
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Of the 107 carcinomas studied, 19 contained pepsinogen II and only 3, found exclusively in pepsinogen II‐positive cases, contained pepsinogen I. Gastric cancer produces pepsinogen II more frequently than pepsinogen I, and production of the latter is significantly associated with the former. Historically, there were 54 intestinal‐type and 53 diffuse‐type cancers. The former produced pepsinogen II more frequently than the latter. In the diffuse type, the four pepsinogen II‐positive cases were found exclusively in females. Although the pepsinogen expression was independent of the macroscopic features in advanced gastric cancer, it was found that the protruded‐type early gastric cancer produced pepsinogen II more frequently than the depressed type. Incidences of pepsinogen positivity were not different between early and advanced gastric cancers or between cancers with or without lymph node metastasis, suggesting that production of pepsinogen is independent of tumor growth.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3143702</pmid><doi>10.1111/j.1349-7006.1988.tb01537.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 0910-5050
ispartof Cancer science, 1988-10, Vol.79 (10), p.1139-1146
issn 0910-5050
1347-9032
1349-7006
1876-4673
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recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5917632
source Publicly Available Content Database; PubMed Central
subjects Aged
Antibodies, Monoclonal
Biological and medical sciences
Carcinoma
Female
Gastric cancer
Gastric Mucosa - enzymology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunohistochemistry
Intestine
Lymph nodes
Lymphatic Metastasis
Male
Medical sciences
Metastases
Middle Aged
Monoclonal antibodies
Monoclonal antibody
Pepsinogen
Pepsinogens - analysis
Stomach Neoplasms - enzymology
Stomach Neoplasms - pathology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
title Pepsinogens I and II in Gastric Cancer: An Immunohistochemical Study Using Monoclonal Antibodies
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