Adult T‐cell Leukemia in Spouses

A married couple who developed adult T‐cell leukemia (ATL) is described. The husband presented with acute ATL and died soon after admission in spite of aggressive chemotherapy, and his wife, who is diagnosed as smoldering ATL, has been followed in the out‐patient clinic. The couple had serum antibod...

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Bibliographic Details
Published in:Cancer science 1989-05, Vol.80 (5), p.401-404
Main Authors: Sanada, Isao, Yamaguchi, Kazunari, Yoshida, Mitsuaki, Ishii, Toshinori, Tsukamoto, Atsuko, Sato, Masahiko, Obata, Shin‐ichiro, Shido, Tadahiro
Format: Article
Language:English
Subjects:
Adult T‐cell leukemia
AIDS/HIV
Biological and medical sciences
Chemotherapy
Familial occurrence
Female
Hematologic and hematopoietic diseases
Horizontal transmission of HTLV‐I
HTLV-I Antibodies - analysis
HTLV‐I
Humans
Leukemia
Leukemia-Lymphoma, Adult T-Cell - transmission
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphocytes
Male
Marriage
Medical sciences
Middle Aged
Rapid Communication
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Summary:A married couple who developed adult T‐cell leukemia (ATL) is described. The husband presented with acute ATL and died soon after admission in spite of aggressive chemotherapy, and his wife, who is diagnosed as smoldering ATL, has been followed in the out‐patient clinic. The couple had serum antibodies against human T‐cell leukemia virus type I (MTLV‐I) and the monoclonal integration of HTLV‐I proviral DNA in their lymphocytes. The patients described represent the first reported example of ATL in a married couple.
ISSN:0910-5050
1347-9032
1349-7006
1876-4673
DOI:10.1111/j.1349-7006.1989.tb02326.x