High Risk of Mother‐to‐Child Transmission of HTLV‐I in p40tax Antibody‐positive Mothers

A new enzyme‐linked immunosorbent assay (ELISA) for detecting the antibody to a human T‐lymphotropic virus type I (HTLV‐I) tax gene product, p40tax, has been developed. By this ELISA method, we have investigated the relationship between the presence of p40tax antibody in HTLV‐I‐infected mothers and...

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Bibliographic Details
Published in:Japanese Journal of Cancer Research 1989-06, Vol.80 (6), p.506-508
Main Authors: Sawada, Takashi, Tohmatsu, Junichi, Obara, Takashi, Koide, Atsushi, Kamihira, Shimeru, Ichimaru, Michito, Kashiwagi, Seizaburo, Kajiyama, Wataru, Matsumura, Nobuyuki, Kinoshita, Kenichiro, Yano, Michitami, Yamaguchi, Kazunari, Kiyokawa, Tetsuyuki, Takatsuki, Kiyoshi, Taguchi, Hirokuni, Miyoshi, Isao
Format: Article
Language:English
Subjects:
Adolescent
Adult
AIDS/HIV
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
HTLV-I Antibodies - analysis
HTLV-I Antigens - immunology
HTLV-I Infections - immunology
HTLV-I Infections - transmission
HTLV‐I
Humans
Lactation
Middle Aged
Mother‐to‐child transmission
p40tax antibody
Pregnancy
Rapid Communication
Risk Factors
Trans-Activators
Transcription Factors - immunology
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Summary:A new enzyme‐linked immunosorbent assay (ELISA) for detecting the antibody to a human T‐lymphotropic virus type I (HTLV‐I) tax gene product, p40tax, has been developed. By this ELISA method, we have investigated the relationship between the presence of p40tax antibody in HTLV‐I‐infected mothers and the virus transmission rate from mothers to their children. The rate of mother‐to‐child transmission of HTLV‐I was higher in P40tax antibody‐positive mothers than in antibody‐negative ones. Thus, the presence of P40tax antibody may indicate an increased risk of vertical transmission of HTLV‐I.
ISSN:0910-5050
1349-7006
1876-4673
DOI:10.1111/j.1349-7006.1989.tb01667.x