A Structural Protein Encoded by the 5′ Region of the Hepatitis C Virus Genome Efficiently Detects Viral Infection

A structural region of the hepatitis C virus genome was molecularly cloned. A protein expressed in vitro by transcription followed by translation was precipitated immunologically by sera from patients with chronic hepatitis or hepatocellular carcinoma that were positive for antibody against the non‐...

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Bibliographic Details
Published in:Cancer science 1990-11, Vol.81 (11), p.1092-1094
Main Authors: Kato, Nobuyuki, Hijikata, Makoto, Ootsuyama, Yuko, Nakagawa, Masanori, Ohkoshi, Showgo, Shimotohno, Kunitada
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Antigens, Viral
Anti‐HCV
Base Sequence
Biological and medical sciences
Carcinoma, Hepatocellular - diagnosis
Cloning, Molecular
Gastroenterology. Liver. Pancreas. Abdomen
Genes, Viral
Genomes
HCV expression
Hepacivirus - genetics
Hepatitis
Hepatitis C
Hepatitis C - diagnosis
Hepatitis C virus (HCV)
Hepatocellular carcinoma
Humans
Interferon
Liver Neoplasms - diagnosis
Medical sciences
Molecular Sequence Data
Open Reading Frames
Proteins
Rapid Communication
Recombinant Proteins - genetics
Transcription
Viral infections
Viral Nonstructural Proteins
Viral Proteins - biosynthesis
Viral Proteins - genetics
Viral Structural Proteins - genetics
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Description
Summary:A structural region of the hepatitis C virus genome was molecularly cloned. A protein expressed in vitro by transcription followed by translation was precipitated immunologically by sera from patients with chronic hepatitis or hepatocellular carcinoma that were positive for antibody against the non‐structural protein, C100, of hepatitis C virus, but not by sera from healthy persons. Thus, this structural protein should be useful for detection of infection with this virus.
ISSN:0910-5050
1347-9032
1349-7006
1876-4673
DOI:10.1111/j.1349-7006.1990.tb02518.x