Inhibitory Effect of Cryptoporic Acid E, a Product from Fungus Cryptoporus volvatus, on Colon Carcinogenesis Induced with N‐Methyl‐N‐Nitrosourea in Rats and with 1,2‐Dimethylhydrazine in Mice

• Published in: Cancer science 1992-08, Vol.83 (8), p.830-834
• Main Authors: Narisawa, Tomio, Fukaura, Yoko, Kotanagi, Hitoshi, Asakawa, Yoshinori
• Format: Article
• Language: English
• Subjects: 1,2-Dimethylhydrazine; Animal tumors. Experimental tumors; Animals; Anticarcinogenic Agents - pharmacology; Biological and medical sciences; Biomarkers, Tumor - analysis; Body weight; Cancer chemoprevention; Carcinogenesis; Carcinogens; Carcinogens - toxicity; Colon; Colon - drug effects; Colon - pathology; Colon cancer; Colon carcinogenesis; Colonic Neoplasms - chemically induced; Colonic Neoplasms - prevention & control; Cryptoporic acid E; Cryptoporus volvatus; Deoxycholic acid; Deoxycholic Acid - pharmacology; Diet; Dimethylhydrazines - toxicity; Enzyme Induction; Experimental digestive system and abdominal tumors; Feeding Behavior - drug effects; Female; Fungi; Intestinal Mucosa - drug effects; Intestinal Mucosa - enzymology; Intestinal Mucosa - pathology; Key words; Medical sciences; Methylnitrosourea - toxicity; Mice; Mice, Inbred ICR; Mucosa; Ornithine; Ornithine decarboxylase; Ornithine Decarboxylase - analysis; Ornithine Decarboxylase - biosynthesis; Polyporaceae; Rats; Rats, Inbred F344; Sesquiterpenes - pharmacology; Tumors; Weight Gain - drug effects
• ISSN: 0910-5050; 1347-9032; 1349-7006; 1876-4673
• DOI: 10.1111/j.1349-7006.1992.tb01987.x

The antitumorigenic effect of cryptoporic acid E (CPA‐E), a dimeric drimane sesquiterpenoid isolated from the fungus Cryptoporus volvatus, on colon carcinogenesis was investigated. Female F344 rats given an intrarectal instillation of 2 mg of N‐methyl‐N‐nitrosourea 3 times weekly in weeks 1 and 2 were fed diet containing 0.2% CPA‐E from week 3. Femal ICR mice given 15 weekly intraperitoneal injections of 10 mg of 1,2‐dimethylhydrazine/kg body weight during weeks 1 to 15 were fed diet containing 0.06% CPA‐E from week 1. The experiment was terminated at week 35 for rats and at week 25 for mice. The incidence and the number of tumors per animal were reduced in CPA‐E‐fed animals compared to the controls: 31% vs. 75% (P P>0.05) in rats, and 31% vs. 63% (0.1>P>0.05) and 0.4±0.2 vs. 2.4 ± 0.8 (P