Integrative metabolic and microbial profiling on patients with Spleen-yang-deficiency syndrome

Gut microbiota is recognized as an indispensable “metabolic organ” that plays crucial roles in maintaining human health or initiating diseases. Spleen-yang-deficiency syndrome (SYDS) is a common syndrome of Traditional Chinese Medicine (TCM) clinic. It is a complex phenotype reflecting the overall c...

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Bibliographic Details
Published in:Scientific reports 2018-04, Vol.8 (1), p.6619-11, Article 6619
Main Authors: Lin, Zhang, Ye, Wu, Zu, Xianpeng, Xie, Haisheng, Li, Houkai, Li, Yiping, Zhang, Weidong
Format: Article
Language:English
Subjects:
101/58
631/1647/2163
631/326/2565/2134
631/45/320
692/699/1503/2745
Digestive system
Dysbacteriosis
Gastrointestinal tract
Herbal medicine
Humanities and Social Sciences
Intestinal microflora
Metabolic disorders
Metabolism
Metabolites
Metabolomics
Microbiota
Mucosa
multidisciplinary
Phenotypes
Polysaccharides
rRNA
Saccharides
Science
Science (multidisciplinary)
Spleen
Traditional Chinese medicine
Urine
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Summary:Gut microbiota is recognized as an indispensable “metabolic organ” that plays crucial roles in maintaining human health or initiating diseases. Spleen-yang-deficiency syndrome (SYDS) is a common syndrome of Traditional Chinese Medicine (TCM) clinic. It is a complex phenotype reflecting the overall changes of metabolism which are mainly caused by digestive disorders. However, little is known about the changes of gut microbiota and metabolism in patients with SYDS, as well as the crosstalk between gut microbiota and host metabolism. In the current study, an integrative metabolic and microbial profiling was performed on plasma, urine and feces from recruited SYDS and healthy individuals by using a LC-QTOFMS-based metabolomic and 16 s rRNA sequencing approaches. Our results showed a potentially significant contribution of gut dysbiosis to the metabolic disorders in SYDS. By integrating the differential gut bacteria with the metabolites, the results revealed some active bacterium of norank_f_ CFT112H7 , f_ lachnospiraceae and bacteroides were closely involved in host mucosal integrity, bile acid metabolism and polysaccharides decomposition. Therefore, our results indicated the probable involvement of gut microbiota in mediating the metabolic changes, which warrants a further investigation on the role of gut microbiota in modulating the pathogenesis of SYDS.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-24130-7