Resveratrol attenuates neurological deficit and neuroinflammation following intracerebral hemorrhage

Resveratrol (RESV) improves histopathological and behavioral outcomes in diseases of the central nervous system. However, to the best of our knowledge, there have been no studies investigating its neuroprotective effects on secondary brain injury following intracerebral hemorrhage (ICH). The aim of...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2018-05, Vol.15 (5), p.4131-4138
Main Authors: Cai, Jia-Chen, Liu, Wei, Lu, Fei, Kong, Wen-Bing, Zhou, Xin-Xuan, Miao, Peng, Lei, Cheng-Xiang, Wang, Yan
Format: Article
Language:English
Subjects:
Behavior
Brain injuries
Brain-derived neurotrophic factor
Care and treatment
Clinical trials
Complications and side effects
Edema
Hemorrhage
Hypertension
Intracerebral hemorrhage
Laboratory animals
Life sciences
Resveratrol
Risk factors
Rodents
Stem cells
Studies
Surgery
Traumatic brain injury
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Summary:Resveratrol (RESV) improves histopathological and behavioral outcomes in diseases of the central nervous system. However, to the best of our knowledge, there have been no studies investigating its neuroprotective effects on secondary brain injury following intracerebral hemorrhage (ICH). The aim of the present study was to evaluate the neuroprotective function of resveratrol following ICH. Male Sprague-Dawley rats were randomly divided into 3 groups: Sham, ICH and ICH+RESV groups. Rats underwent ICH and received an intraperitoneal injection of RESV daily. Rotarod and open field tests were performed to evaluate improvements in motor disturbance pre- and post-surgery. Rats were sacrificed following the final behavioral test; subsequently, neuron injury and cell death in the hippocampus and microglia activation in the cortex were determined using Nissl staining and ionized calcium binding adaptor molecule 1 immunofluorescence staining, respectively. Compared with the ICH group, rats treated with resveratrol for 2 weeks performed significantly better in behavioral tests. Furthermore, less neural damage in the hippocampus and decreased activation of microglia was observed in the ICH+RESV group. The results of the present study therefore indicate that resveratrol may alleviate secondary brain injury following ICH.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2018.5938