Helicobacter pylori Infection, Serum Pepsinogen Level and Gastric Cancer: A Case‐Control Study in Japan

• Published in: Cancer science 1995-01, Vol.86 (1), p.64-71
• Main Authors: Fukuda, Haruhiko, Saito, Daizo, Hayashi, Shuya, Hisai, Hiroyuki, Ono, Hiroyuki, Yoshida, Shigeaki, Oguro, Yanao, Noda, Takeshi, Sato, Toshiya, Katoh, Masaru, Terada, Masaaki, Sugimura, Takashi
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Atrophic gastritis; Atrophy; Biological and medical sciences; Case-Control Studies; Case‐control study; Female; Gastric cancer; Gastritis; Gastroenterology. Liver. Pancreas. Abdomen; Helicobacter Infections - blood; Helicobacter pylori; Humans; Immunoglobulin G; Infections; Intestine; Japan; Male; Medical sciences; Middle Aged; Mucosa; Neoplasm Invasiveness; Odds Ratio; Pepsinogens - blood; Regression Analysis; Serum pepsinogen; Stomach neoplasm; Stomach Neoplasms - blood; Stomach Neoplasms - microbiology; Stomach Neoplasms - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors
• ISSN: 0910-5050; 1347-9032; 1349-7006; 1876-4673
• DOI: 10.1111/j.1349-7006.1995.tb02989.x

We conducted a case‐control study to evaluate the effect of Helicobacter pylori (HP) infection on the risk of gastric cancer in Tokyo, Japan. The sera at the time of diagnosis from 282 gastric cancer cases and 767 sex‐ and age‐matched cancer‐free controls were tested for the presence of anti‐HP IgG antibody (HM‐CAP ELISA kit) and serum pepsinogen (PG) level (PG I and PG II Riabead). No significant association was observed in all sets [matched odds ratio (OR)=1.04, 95% confidence interval: 0.73–1.49]. In subgroup analyses, however, an association was suggested in females [OR=1.57], a younger population (