Frequent Genetic Instability in Small Intestinal Carcinomas

To determine whether genetic instability plays a part in the development of digestive tract carcinomas, we analyzed 3 microsatellite loci isolated from tumors and surrounding normal tissue samples obtained during surgery. The polymerase chain reaction (PCR) technique was used to assess differences b...

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Bibliographic Details
Published in:Cancer science 1995-04, Vol.86 (4), p.357-360
Main Authors: Hibi, Kenji, Kondo, Ken, Akiyama, Seiji, Ito, Katsuki, Takagi, Hiroshi
Format: Article
Language:English
Subjects:
Biological and medical sciences
Colorectal carcinoma
Colorectal Neoplasms - genetics
DNA
DNA Replication - genetics
DNA, Neoplasm - genetics
DNA, Satellite - genetics
Esophageal carcinoma
Esophagus
Gastric cancer
Gastric carcinoma
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal tract
Genetic instability
Genomic instability
Hereditary non‐polyposis colorectal cancer
Humans
Intestinal Neoplasms - genetics
Intestine
Intestine, Small
man
Medical sciences
microsatellites
Polymerase Chain Reaction
Small intestinal carcinoma
small intestine
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Surgery
Tumors
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Summary:To determine whether genetic instability plays a part in the development of digestive tract carcinomas, we analyzed 3 microsatellite loci isolated from tumors and surrounding normal tissue samples obtained during surgery. The polymerase chain reaction (PCR) technique was used to assess differences between tumor and matched normal DNAs. Replication errors (RERs) were observed in 3 of the 29 cases (10%) of gastric carcinoma and in 11 of the 72 cases (15%) of colorectal carcinoma. None of the 13 (0%) esophageal carcinoma cases showed any RER, but 5 of the 11 cases of small intestinal carcinoma (45%) had RERs, a significantly frequent finding. These results suggest that genetic instability plays an important role in the pathogenesis of small intestinal carcinomas.
ISSN:0910-5050
1347-9032
1349-7006
1876-4673
DOI:10.1111/j.1349-7006.1995.tb03064.x