Oral lichen planus and malignant transformation: The role of p16, Ki-67, Bub-3 and SOX4 in assessing precancerous potential

The association of oral lichen planus (OLP) lesions with malignant transformation risk has remained a controversial topic and is of clinical importance. Therefore, the present study evaluated the expression levels of p16, Ki-67, budding uninhibited by benzimidazoles 3 (Bub-3) and sex-determining reg...

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Published in:Experimental and therapeutic medicine 2018-05, Vol.15 (5), p.4157-4166
Main Authors: Rosa, Eduardo Augusto, Hurtado-Puerto, Aura Maria, Falcão, Denise Pinheiro, Brietzke, Aline Patricia, De Almeida Prado Franceschi, Luiz Eduardo, Cavalcanti Neto, Florlorêncio Figueiredo, Tiziane, Valdenize, Carneiro, Fabiana Pirani, Kogawa, Evelyn Mikaela, Moreno, Heitor, Amorim, Rivadávio Fernandes Batista
Format: Article
Language:English
Subjects:
Age
Antigens
Biological markers
Breast cancer
Cell cycle
Females
Gene expression
Genetic aspects
Hyperplasia
Inflammation
Kinases
Lichen planus
Oral cancer
Skin diseases
Studies
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Summary:The association of oral lichen planus (OLP) lesions with malignant transformation risk has remained a controversial topic and is of clinical importance. Therefore, the present study evaluated the expression levels of p16, Ki-67, budding uninhibited by benzimidazoles 3 (Bub-3) and sex-determining region Y-related high mobility group box 4 (SOX4), and their roles as precancerous biomarkers in OLP. A retrospective study was performed, in which tissue blocks of OLP, oral dysplasia (OD), cutaneous lichen planus (CLP) and oral fibrous hyperplasia (OFH) were used (n=120). A positivity index (PI) for p16, BUB3, Ki-67 and SOX4 expression was calculated in each group. The PI for p16 was 20.65% for OLP, 7.85% for OD, 86.59% for CLP and 11.8% for OFH, and the difference between these groups was statistically significant (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2018.5971