Differential Dose‐dependent Effects of α‐, β‐Carotenes and Lycopene on Gap‐junctional Intercellular Communication in Rat Liver in vivo

In order to examine the relevance of alteration of gap‐junctional intercellular communication (GJIC) to chemopreventive activity against carcinogenesis, the effects of α andβ ‐carotene as well as lycopene, typical chemopreventive carotenoids, on cell coupling via gap junctions in rat liver in vivo w...

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Bibliographic Details
Published in:Cancer science 1997-12, Vol.88 (12), p.1121-1124
Main Authors: Krutovskikh, Vladimir, Asamoto, Makoto, Takasuka, Nobuo, Murakoshi, Michiaki, Nishino, Hoyoku, Tsuda, Hiroyuki
Format: Article
Language:English
Subjects:
Animals
Anticarcinogenic Agents - pharmacology
Antineoplastic agents
Antioxidants - pharmacology
beta Carotene - pharmacology
Biological and medical sciences
Body weight
Carcinogenesis
Carotenoid
Carotenoids
Carotenoids - pharmacology
Cell Communication - drug effects
Cell interactions
Cell signaling
Chemoprevention
Chemotherapy
Communication
Dose-Response Relationship, Drug
Gap junction
Gap junctions
Gap Junctions - drug effects
Liver
Liver - drug effects
Liver - pathology
Liver - physiology
Lycopene
Male
Medical sciences
Pharmacology. Drug treatments
Rapid Communication
Rats
Rats, Inbred F344
β-Carotene
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Summary:In order to examine the relevance of alteration of gap‐junctional intercellular communication (GJIC) to chemopreventive activity against carcinogenesis, the effects of α andβ ‐carotene as well as lycopene, typical chemopreventive carotenoids, on cell coupling via gap junctions in rat liver in vivo were studied using a direct functional dye‐transfer technique. We found that all three test compounds given at a dose of 50 mg/kg‐body weight (b.w.) daily, 5 times by gavage, inhibited GJIC, while similar treatment with 5 mg/kg b.w. caused enhancement, especially in the β‐carotene and lycopene‐treated groups. At the dose level of 0.5 mg/kg b.w., the three compounds had no effect. The findings show that all three agents differentially modulate GJIC depending on the dose, with beneficial effects on cell communication only detected at the one dose. The result suggests that determination of the dose of chemicals to be used is crucial for human intervention studies.
ISSN:0910-5050
1347-9032
1349-7006
1876-4673
DOI:10.1111/j.1349-7006.1997.tb00338.x