Inhibitory Effect of Tomato Juice on Rat Urinary Bladder Carcinogenesis after N‐Butyl‐N‐(4‐hydroxybutyl)nitrosamine Initiation

The effects of tomato juice on urinary bladder carcinogenesis were studied in male Fischer 344 rats initiated with N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine (BBN) in rats. The animals (6 weeks old) were given 0.05% BBN in their drinking water for 8 weeks, followed by diluted tomato juice for 12 weeks, a...

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Published in:Cancer science 1998-01, Vol.89 (1), p.22-26
Main Authors: Okajima, Eijiro, Tsutsumi, Masahiro, Ozono, Seiichiro, Akai, Hiroyuki, Denda, Ayumi, Nishino, Hoyoku, Oshima, Syunji, Sakamoto, Hideki, Konishi, Yoichi
Format: Article
Language:English
Subjects:
Animals
Anticarcinogenic Agents - analysis
Antineoplastic agents
Antioxidants - analysis
Biological and medical sciences
Butylhydroxybutylnitrosamine
Carcinogenesis
Carotenoids - analysis
Chemotherapy
Drinking water
Hyperplasia
Juices
Liver - chemistry
Liver - pathology
Lycopene
Lycopersicon esculentum
Male
Medical sciences
N‐Butyl‐N‐(4‐hydroxybutyl)nitrosamine
Organ Size - drug effects
Oxidants
Pharmacology. Drug treatments
Rat urinary bladder carcinogenesis
Rats
Rats, Inbred F344
Tomato juice
Transitional cell carcinoma
Urinary bladder
Urinary bladder carcinoma
Urinary Bladder Neoplasms - chemically induced
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - prevention & control
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Summary:The effects of tomato juice on urinary bladder carcinogenesis were studied in male Fischer 344 rats initiated with N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine (BBN) in rats. The animals (6 weeks old) were given 0.05% BBN in their drinking water for 8 weeks, followed by diluted tomato juice for 12 weeks, and killed at 20 weeks after the beginning of the experiment. Lycopene concentrations in the livers of rats given tomato juice were elevated. Histopathological analysis of urinary bladder lesions revealed the numbers, but not incidences, of urinary bladder transitional cell carcinomas (TCCs) to be decreased in the group given tomato juice. No influence on the incidence of simple and nodullopapillary hyperplasias, invasion or differentiation of TCC was noted. These results indicate that tomato juice, presumably the contained lycopene and other anti‐oxidants in combination, exerts an inhibitory effect on the development of TCCs in the rat urinary bladder.
ISSN:0910-5050
1347-9032
1349-7006
1876-4673
DOI:10.1111/j.1349-7006.1998.tb00474.x