A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens

The efficacy of subcutaneously administered polymyxins against burn wound infections caused by , , and was examined in a murine infection model. Subcutaneously administered colistin and polymyxin B (30 mg/kg thrice daily) achieved a ≥2-log reduction in the bacterial load for and infections, whereas...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2018-05, Vol.62 (5)
Main Authors: Lin, Yu-Wei, Chen, Ke, Wang, Jiping, Velkov, Tony, Zhou, Qi Tony, Li, Jian
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents
Anti-Bacterial Agents - therapeutic use
Burns
Burns - microbiology
Drug Resistance, Multiple, Bacterial
Female
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - pathogenicity
Mice
Microbial Sensitivity Tests
Pharmacology
Polymyxins
Polymyxins - therapeutic use
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - pathogenicity
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Summary:The efficacy of subcutaneously administered polymyxins against burn wound infections caused by , , and was examined in a murine infection model. Subcutaneously administered colistin and polymyxin B (30 mg/kg thrice daily) achieved a ≥2-log reduction in the bacterial load for and infections, whereas wound infections by were less responsive (
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02527-17