In Vitro Antifungal Activity of Novel Triazole Efinaconazole and Five Comparators against Dermatophyte Isolates

The objective of this study was to assess the activity of the novel triazole antifungal drug, efinaconazole, and five comparators (luliconazole, lanoconazole, terbinafine, itraconazole, and fluconazole) against a large collection of and clinical isolates. The geometric mean MICs were the lowest for...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2018-05, Vol.62 (5)
Main Authors: Rezaei-Matehkolaei, Ali, Khodavaisy, Sadegh, Alshahni, Mohamad Mahdi, Tamura, Takashi, Satoh, Kazuo, Abastabar, Mahdi, Shokoohi, Gholam Reza, Ahmadi, Bahram, Kord, Mohammad, Taghipour, Simin, Makimura, Koichi, Badali, Hamid
Format: Article
Language:English
Subjects:
Antifungal Agents
Arthrodermataceae
Susceptibility
Triazoles
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Summary:The objective of this study was to assess the activity of the novel triazole antifungal drug, efinaconazole, and five comparators (luliconazole, lanoconazole, terbinafine, itraconazole, and fluconazole) against a large collection of and clinical isolates. The geometric mean MICs were the lowest for luliconazole (0.0005 μg/ml), followed by lanoconazole (0.002 μg/ml), efinaconazole (0.007 μg/ml), terbinafine (0.011 μg/ml), itraconazole (0.095 μg/ml), and fluconazole (12.77 μg/ml). It appears that efinaconazole, lanoconazole, and luliconazole are promising candidates for the treatment of dermatophytosis due to and .
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02423-17