Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System

The molecular mechanisms of tolerance and persistence associated with several compounds in clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imip...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2018-05, Vol.62 (5)
Main Authors: Fernández-García, Laura, Fernandez-Cuenca, Felipe, Blasco, Lucía, López-Rojas, Rafael, Ambroa, Anton, Lopez, María, Pascual, Álvaro, Bou, Germán, Tomás, María
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Anti-Bacterial Agents
beta-Lactamases
Chlorhexidine
Drug Tolerance
Imipenem
Mechanisms of Action: Physiological Effects
Toxin-Antitoxin Systems
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Summary:The molecular mechanisms of tolerance and persistence associated with several compounds in clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00250-18