Current Methods for Skeletal Muscle Tissue Repair and Regeneration

Skeletal muscle has the capacity of regeneration after injury. However, for large volumes of muscle loss, this regeneration needs interventional support. Consequently, muscle injury provides an ongoing reconstructive and regenerative challenge in clinical work. To promote muscle repair and regenerat...

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Bibliographic Details
Published in:BioMed research international 2018-01, Vol.2018 (2018), p.1-11
Main Authors: Lehman, Wolfgang, Ernst, Jennifer, Böker, Kai Oliver, Saul, Dominik, Liu, Juan, Schilling, Arndt F.
Format: Article
Language:English
Subjects:
Analysis
Animals
Biological products
Biomaterials
Biomedical materials
Epidemiology
Fibroblasts
Humans
Immunology
Injuries
Muscle, Skeletal - pathology
Muscle, Skeletal - physiopathology
Muscles
Muscular dystrophy
Musculoskeletal system
Myogenesis
Neurosciences
Physical therapy
Protein synthesis
Proteins
Regeneration
Repair
Review
Skeletal muscle
Stem cells
Surgery
Surgical techniques
Therapeutics, Physiological
Tissue engineering
Tissue Engineering - methods
Trauma
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Summary:Skeletal muscle has the capacity of regeneration after injury. However, for large volumes of muscle loss, this regeneration needs interventional support. Consequently, muscle injury provides an ongoing reconstructive and regenerative challenge in clinical work. To promote muscle repair and regeneration, different strategies have been developed within the last century and especially during the last few decades, including surgical techniques, physical therapy, biomaterials, and muscular tissue engineering as well as cell therapy. Still, there is a great need to develop new methods and materials, which promote skeletal muscle repair and functional regeneration. In this review, we give a comprehensive overview over the epidemiology of muscle tissue loss, highlight current strategies in clinical treatment, and discuss novel methods for muscle regeneration and challenges for their future clinical translation.
ISSN:2314-6133
2314-6141
DOI:10.1155/2018/1984879