Mitochondrial regulation of hematopoietic stem cells

Hematopoietic stem cells (HSCs) preferentially use glycolysis rather than mitochondrial oxidative phosphorylation for energy production. While glycolysis in HSC is typically viewed as response to a hypoxic bone marrow environment that protects HSC from damaging reactive oxygen species, other interpr...

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Bibliographic Details
Published in:Current opinion in cell biology 2017-12, Vol.49, p.91-98
Main Author: Snoeck, Hans-Willem
Format: Article
Language:English
Subjects:
Hematopoietic Stem Cells - metabolism
Humans
Mitochondria - metabolism
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Summary:Hematopoietic stem cells (HSCs) preferentially use glycolysis rather than mitochondrial oxidative phosphorylation for energy production. While glycolysis in HSC is typically viewed as response to a hypoxic bone marrow environment that protects HSC from damaging reactive oxygen species, other interpretations are possible. Furthermore, recent evidence directly supports a critical role for mitochondria in the maintenance and function of HSCs that goes beyond ATP production. Here, we review recent advances in our understanding of metabolism and the role of mitochondria in the biology of HSCs.
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2017.12.010