In vitro study on role of σB protein in avian reovirus pathogenesis

Avian reoviruses, members of genus was known to cause diseases like tenosynovitis, runting-stunting syndrome in chickens. Among eight structural proteins, the proteins of S-class are mainly associated with viral arthritis but the significance of σB protein in arthritis is not established till date....

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Published in:Oncotarget 2018-04, Vol.9 (28), p.19569-19583
Main Authors: Praharaj, Manas R, Sahoo, Aditya P, Chauhan, Tapan K S, Gandham, Ravi Kumar, Saxena, Shikha, Agarwal, Ravi K, Dhama, Kuldeep, Mishra, Bina, Marriappan, Asok K, Tiwari, Ashok K, Goswami, Puroshottam Prasad, Mishra, Bishnu Prasad, Kumar, Deepak
Format: Article
Language:English
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Research Paper
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Summary:Avian reoviruses, members of genus was known to cause diseases like tenosynovitis, runting-stunting syndrome in chickens. Among eight structural proteins, the proteins of S-class are mainly associated with viral arthritis but the significance of σB protein in arthritis is not established till date. In this infection pathological condition together with infection of joints often leads to arthritis because joints consists of cartilage which forms lubricating surface between two bones, and has limited metabolic, replicative and repair capacity. To establish the role of σB protein in arthritis, an microarray study was conducted consisting four groups viz. virus infected and control; pDsRed-Express-N1-σB and empty pDs-Red transfected, CEF cells. With cut-off value as FC ≥2, p value
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.24668