Cell Polarity: Netrin Calms an Excitable System

In a tractable model for cell invasion, the Caenorhabditis elegans anchor cell migrates through basement membranes towards a polarity cue provided by netrin. A new study reveals that the anchor cell polarity network can break symmetry and oscillate in the absence of netrin, suggesting the presence o...

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Bibliographic Details
Published in:Current biology 2014-11, Vol.24 (21), p.R1050-R1052
Main Authors: McClure, Allison W., Lew, Daniel J.
Format: Article
Language:English
Subjects:
Animals
Caenorhabditis elegans - cytology
Caenorhabditis elegans Proteins - metabolism
Caenorhabditis elegans Proteins - physiology
Cell Adhesion Molecules - metabolism
Female
Nerve Tissue Proteins - physiology
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Summary:In a tractable model for cell invasion, the Caenorhabditis elegans anchor cell migrates through basement membranes towards a polarity cue provided by netrin. A new study reveals that the anchor cell polarity network can break symmetry and oscillate in the absence of netrin, suggesting the presence of interlinked positive and negative feedback loops, which are common in polarity pathways.
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2014.09.042