Myoclonus from Antibiotic Therapy (Ceftazidime-induced Neurotoxicity): A Case Report and Review

A 78-year-old Chinese man with a history of end-stage renal disease (ESRD) presented with fever of one-day duration. He was treated for catheter-related sepsis with intravenous piperacillin and tazobactam, which was later switched to vancomycin and ceftazidime secondary to persistent fever with nega...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2018-03, Vol.10 (3), p.e2250
Main Authors: Ong, Chong Yau, Qin, Yan
Format: Article
Language:English
Subjects:
Antibiotics
Ataxia
Case reports
Ear diseases
Electroencephalography
Fever
Hospitals
Infections
Internal Medicine
Kidney diseases
Neurology
Neurotoxicity
NMR
Nuclear magnetic resonance
Other
Parasites
Patients
Peritoneal dialysis
Pneumonia
Urine
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Summary:A 78-year-old Chinese man with a history of end-stage renal disease (ESRD) presented with fever of one-day duration. He was treated for catheter-related sepsis with intravenous piperacillin and tazobactam, which was later switched to vancomycin and ceftazidime secondary to persistent fever with negative cultures. On the fifth day of treatment with vancomycin and ceftazidime, he developed new-onset upper limb myoclonus which progressed to bilateral upper limb ataxia. A provisional diagnosis of myoclonus and ataxia secondary to neurotoxicity related to ceftazidime was made and the ceftazidime was ceased. His symptoms resolved over three days and he returned to his baseline neurological status by day 5 following cessation.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.2250