Loading…

Myoclonus from Antibiotic Therapy (Ceftazidime-induced Neurotoxicity): A Case Report and Review

A 78-year-old Chinese man with a history of end-stage renal disease (ESRD) presented with fever of one-day duration. He was treated for catheter-related sepsis with intravenous piperacillin and tazobactam, which was later switched to vancomycin and ceftazidime secondary to persistent fever with nega...

Full description

Saved in:
Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2018-03, Vol.10 (3), p.e2250
Main Authors: Ong, Chong Yau, Qin, Yan
Format: Article
Language:English
Subjects:
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c372t-214b54d7980ea23701ca92cf1ebe5e853ef570d36a8f36fdc11d7882c2a45ac23
cites
container_end_page
container_issue 3
container_start_page e2250
container_title Curēus (Palo Alto, CA)
container_volume 10
creator Ong, Chong Yau
Qin, Yan
description A 78-year-old Chinese man with a history of end-stage renal disease (ESRD) presented with fever of one-day duration. He was treated for catheter-related sepsis with intravenous piperacillin and tazobactam, which was later switched to vancomycin and ceftazidime secondary to persistent fever with negative cultures. On the fifth day of treatment with vancomycin and ceftazidime, he developed new-onset upper limb myoclonus which progressed to bilateral upper limb ataxia. A provisional diagnosis of myoclonus and ataxia secondary to neurotoxicity related to ceftazidime was made and the ceftazidime was ceased. His symptoms resolved over three days and he returned to his baseline neurological status by day 5 following cessation.
doi_str_mv 10.7759/cureus.2250
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5929940</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2047927708</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-214b54d7980ea23701ca92cf1ebe5e853ef570d36a8f36fdc11d7882c2a45ac23</originalsourceid><addsrcrecordid>eNpVkc1LAzEQxYMoWtSTdwl4UWQ1ye42iQehFL-gKoieQ5rM2pR2U5Nstf71bmmVepoH8-PNYx5CR5RccF7KS9MEaOIFYyXZQh1GuyITVBTbG3oPHcY4JoRQwhnhZBftMckZzaXoIPW48Gbi6ybiKvgp7tXJDZ1PzuDXEQQ9W-DTPlRJfzvrppC52jYGLH6CJvjkv5xxaXF2hXu4ryPgF5j5kLCubSvnDj4P0E6lJxEO13Mfvd3evPbvs8Hz3UO_N8hMzlnKGC2GZWG5FAQ0yzmhRktmKgpDKEGUOVQlJzbvalHl3coaSi0Xghmmi1Iblu-j65XvrBlOwRqoU9ATNQtuqsNCee3U_03tRurdz1UpmZQFaQ1O1gbBfzQQkxr7JtRtZsVIwSXjnIiWOl9RJvgYA1R_FyhRy0LUqhC1LKSljzdD_bG_789_APHmiQ8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2047927708</pqid></control><display><type>article</type><title>Myoclonus from Antibiotic Therapy (Ceftazidime-induced Neurotoxicity): A Case Report and Review</title><source>PubMed (Medline)</source><source>Publicly Available Content Database</source><creator>Ong, Chong Yau ; Qin, Yan</creator><creatorcontrib>Ong, Chong Yau ; Qin, Yan</creatorcontrib><description>A 78-year-old Chinese man with a history of end-stage renal disease (ESRD) presented with fever of one-day duration. He was treated for catheter-related sepsis with intravenous piperacillin and tazobactam, which was later switched to vancomycin and ceftazidime secondary to persistent fever with negative cultures. On the fifth day of treatment with vancomycin and ceftazidime, he developed new-onset upper limb myoclonus which progressed to bilateral upper limb ataxia. A provisional diagnosis of myoclonus and ataxia secondary to neurotoxicity related to ceftazidime was made and the ceftazidime was ceased. His symptoms resolved over three days and he returned to his baseline neurological status by day 5 following cessation.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.2250</identifier><identifier>PMID: 29721398</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Antibiotics ; Ataxia ; Case reports ; Ear diseases ; Electroencephalography ; Fever ; Hospitals ; Infections ; Internal Medicine ; Kidney diseases ; Neurology ; Neurotoxicity ; NMR ; Nuclear magnetic resonance ; Other ; Parasites ; Patients ; Peritoneal dialysis ; Pneumonia ; Urine</subject><ispartof>Curēus (Palo Alto, CA), 2018-03, Vol.10 (3), p.e2250</ispartof><rights>Copyright © 2018, Ong et al. This work is published under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2018, Ong et al. 2018 Ong et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-214b54d7980ea23701ca92cf1ebe5e853ef570d36a8f36fdc11d7882c2a45ac23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2047927708/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2047927708?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29721398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ong, Chong Yau</creatorcontrib><creatorcontrib>Qin, Yan</creatorcontrib><title>Myoclonus from Antibiotic Therapy (Ceftazidime-induced Neurotoxicity): A Case Report and Review</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>A 78-year-old Chinese man with a history of end-stage renal disease (ESRD) presented with fever of one-day duration. He was treated for catheter-related sepsis with intravenous piperacillin and tazobactam, which was later switched to vancomycin and ceftazidime secondary to persistent fever with negative cultures. On the fifth day of treatment with vancomycin and ceftazidime, he developed new-onset upper limb myoclonus which progressed to bilateral upper limb ataxia. A provisional diagnosis of myoclonus and ataxia secondary to neurotoxicity related to ceftazidime was made and the ceftazidime was ceased. His symptoms resolved over three days and he returned to his baseline neurological status by day 5 following cessation.</description><subject>Antibiotics</subject><subject>Ataxia</subject><subject>Case reports</subject><subject>Ear diseases</subject><subject>Electroencephalography</subject><subject>Fever</subject><subject>Hospitals</subject><subject>Infections</subject><subject>Internal Medicine</subject><subject>Kidney diseases</subject><subject>Neurology</subject><subject>Neurotoxicity</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Other</subject><subject>Parasites</subject><subject>Patients</subject><subject>Peritoneal dialysis</subject><subject>Pneumonia</subject><subject>Urine</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpVkc1LAzEQxYMoWtSTdwl4UWQ1ye42iQehFL-gKoieQ5rM2pR2U5Nstf71bmmVepoH8-PNYx5CR5RccF7KS9MEaOIFYyXZQh1GuyITVBTbG3oPHcY4JoRQwhnhZBftMckZzaXoIPW48Gbi6ybiKvgp7tXJDZ1PzuDXEQQ9W-DTPlRJfzvrppC52jYGLH6CJvjkv5xxaXF2hXu4ryPgF5j5kLCubSvnDj4P0E6lJxEO13Mfvd3evPbvs8Hz3UO_N8hMzlnKGC2GZWG5FAQ0yzmhRktmKgpDKEGUOVQlJzbvalHl3coaSi0Xghmmi1Iblu-j65XvrBlOwRqoU9ATNQtuqsNCee3U_03tRurdz1UpmZQFaQ1O1gbBfzQQkxr7JtRtZsVIwSXjnIiWOl9RJvgYA1R_FyhRy0LUqhC1LKSljzdD_bG_789_APHmiQ8</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Ong, Chong Yau</creator><creator>Qin, Yan</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20180301</creationdate><title>Myoclonus from Antibiotic Therapy (Ceftazidime-induced Neurotoxicity): A Case Report and Review</title><author>Ong, Chong Yau ; Qin, Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-214b54d7980ea23701ca92cf1ebe5e853ef570d36a8f36fdc11d7882c2a45ac23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antibiotics</topic><topic>Ataxia</topic><topic>Case reports</topic><topic>Ear diseases</topic><topic>Electroencephalography</topic><topic>Fever</topic><topic>Hospitals</topic><topic>Infections</topic><topic>Internal Medicine</topic><topic>Kidney diseases</topic><topic>Neurology</topic><topic>Neurotoxicity</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Other</topic><topic>Parasites</topic><topic>Patients</topic><topic>Peritoneal dialysis</topic><topic>Pneumonia</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ong, Chong Yau</creatorcontrib><creatorcontrib>Qin, Yan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ong, Chong Yau</au><au>Qin, Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myoclonus from Antibiotic Therapy (Ceftazidime-induced Neurotoxicity): A Case Report and Review</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>10</volume><issue>3</issue><spage>e2250</spage><pages>e2250-</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>A 78-year-old Chinese man with a history of end-stage renal disease (ESRD) presented with fever of one-day duration. He was treated for catheter-related sepsis with intravenous piperacillin and tazobactam, which was later switched to vancomycin and ceftazidime secondary to persistent fever with negative cultures. On the fifth day of treatment with vancomycin and ceftazidime, he developed new-onset upper limb myoclonus which progressed to bilateral upper limb ataxia. A provisional diagnosis of myoclonus and ataxia secondary to neurotoxicity related to ceftazidime was made and the ceftazidime was ceased. His symptoms resolved over three days and he returned to his baseline neurological status by day 5 following cessation.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>29721398</pmid><doi>10.7759/cureus.2250</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2168-8184
ispartof Curēus (Palo Alto, CA), 2018-03, Vol.10 (3), p.e2250
issn 2168-8184
2168-8184
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5929940
source PubMed (Medline); Publicly Available Content Database
subjects Antibiotics
Ataxia
Case reports
Ear diseases
Electroencephalography
Fever
Hospitals
Infections
Internal Medicine
Kidney diseases
Neurology
Neurotoxicity
NMR
Nuclear magnetic resonance
Other
Parasites
Patients
Peritoneal dialysis
Pneumonia
Urine
title Myoclonus from Antibiotic Therapy (Ceftazidime-induced Neurotoxicity): A Case Report and Review
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T23%3A28%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Myoclonus%20from%20Antibiotic%20Therapy%20(Ceftazidime-induced%20Neurotoxicity):%20A%20Case%20Report%20and%20Review&rft.jtitle=Cur%C4%93us%20(Palo%20Alto,%20CA)&rft.au=Ong,%20Chong%20Yau&rft.date=2018-03-01&rft.volume=10&rft.issue=3&rft.spage=e2250&rft.pages=e2250-&rft.issn=2168-8184&rft.eissn=2168-8184&rft_id=info:doi/10.7759/cureus.2250&rft_dat=%3Cproquest_pubme%3E2047927708%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c372t-214b54d7980ea23701ca92cf1ebe5e853ef570d36a8f36fdc11d7882c2a45ac23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2047927708&rft_id=info:pmid/29721398&rfr_iscdi=true